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Chloroform toxicity

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Revision as of 23:22, 5 April 2017 by Bisakson (Talk | contribs) (Created page with "==Background== *Chloroform (Trichloromethane) is a chlorinated hydrocarbon *Solvent used in chemical and pharmaceutical industries ==Mechanism of Toxicity== *CNS depressant *...")

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Contents

1 Background
2 Mechanism of Toxicity
3 Clinical Presentation
4 Diagnosis
5 Treatment
6 See Also
7 External Links
8 References

Background

Chloroform (Trichloromethane) is a chlorinated hydrocarbon
Solvent used in chemical and pharmaceutical industries

Mechanism of Toxicity

CNS depressant
Hepatic and renal toxicity via free radical formation
Arrhythmogenesis
Carcinogenesis

Clinical Presentation

Nausea
Vomiting
Headache
Confusion
Cardiac arrhythmia
Coma
Renal/Hepatic impairment

Diagnosis

Based on clinical presentation
Specific levels rarely available

Treatment

Decontamination
Avoid sympathomimetics like epinephrine which may trigger arrhythmia
N-acetylcysteine may minimize renal and hepatic toxicity

See Also

External Links

References

Olson, K. Poisoning and Drug Overdose, 1999.

Authors

Ben Isakson, Ross Donaldson, Michael O'Brien, MD

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