ATSDR - Toxic Substances - 1,4-Dioxane
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1,4-Dioxane

CAS ID #: 123-91-1

Affected Organ Systems: Hepatic (Liver), Ocular (Eyes), Renal (Urinary System or Kidneys)

Cancer Classification: EPA: Likely to be carcinogenic to humans. IARC: Possibly carcinogenic to humans. NTP: Reasonably anticipated to be a human carcinogen

Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification.

Chemical Classification: None

Summary: 1,4-Dioxane is a clear liquid that easily dissolves in water. It is used primarily as a solvent in the manufacture of chemicals and as a laboratory reagent; 1,4-dioxane also has various other uses that take advantage of its solvent properties. 1,4-Dioxane is a trace contaminant of some chemicals used in cosmetics, detergents, and shampoos. However, manufacturers now reduce 1,4-dioxane from these chemicals to low levels before these chemicals are made into products used in the home.

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