Zinc sulfate (medical use)

Zinc sulfate
	Chemical model
Clinical data
Trade names	Solvazinc, Micro-Zn, others
AHFS/Drugs.com	Consumer Drug Information
Pregnancy; category	US: A (No risk in human studies) and C;
Routes of; administration	by mouth, intravenous
Drug class	mineral supplement
ATC code	A12CB01 (WHO) ;
Identifiers
	IUPAC name Zinc sulfate;
CAS Number	7733-02-0;
PubChem CID	24424;
DrugBank	DB09322;
ChemSpider	22833;
UNII	0J6Z13X3WO;
ChEBI	CHEBI:35176;
ChEMBL	ChEMBL1200929;
Chemical and physical data
Formula	ZnSO4
Molar mass	161.47
3D model (JSmol)	Interactive image;
	SMILES [O-]S(=O)(=O)[O-].[Zn+2];
	InChI InChI=1S/H2O4S.Zn/c1-5(2,3)4;/h(H2,1,2,3,4);/q;+2/p-2; Key:NWONKYPBYAMBJT-UHFFFAOYSA-L;

Zinc sulfate is used medically as a dietary supplement.[1] Specifically it is used to treat zinc deficiency and to prevention the conditions in those at high risk.[1] This includes use together with oral rehydration therapy for children who have diarrhea.[2] General use is not recommended.[1] It may be taken by mouth or by injection into a vein.[1]

Side effects may include abdominal pain, vomiting, headache, and feeling tired.[2] While normal doses are deemed safe in pregnancy and breastfeeding, the safety of larger doses is unclear.[3] Greater care should be taken in those with kidney problems.[2] Zinc is an essential mineral in people as well as other animals.[4]

The medical use of zinc sulfate began as early as the 1600s.[5] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] Zinc sulfate is available as a generic medication and over the counter.[1][3] The wholesale cost in the developing world is about US$0.01–18 per day.[7] In the United Kingdom ten days of treatment costs the NHS about 4.32 pounds.[1]

Medical uses

The use of zinc sulfate supplements together with oral rehydration therapy decreases the number of bowel movements and the time until the diarrhea stops.[2] It general use in this situation is thus recommended by the World Health Organization.[2]

Zinc sulfate is also an important part of parenteral nutrition.[1]

British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 700. ISBN 9780857111562.
WHO Model Formulary 2008 (PDF). World Health Organization. 2009. pp. 349–351. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.
"Zinc sulfate Use During Pregnancy | Drugs.com". www.drugs.com. Archived from the original on 16 September 2016. Retrieved 15 January 2017.
Council, National Research; Studies, Division on Earth and Life; Resources, Board on Agriculture and Natural; Animals, Committee on Minerals and Toxic Substances in Diets and Water for (2006). Mineral Tolerance of Animals: Second Revised Edition, 2005. National Academies Press. p. 420. ISBN 9780309096546. Archived from the original on 2017-01-16.
Sneader, Walter (2005). Drug Discovery: A History. John Wiley & Sons. p. 62. ISBN 9780471899792. Archived from the original on 2017-01-16.
"WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
"Zinc Sulfate". International Drug Price Indicator Guide. Retrieved 8 December 2016.

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