Vacuolization

Vacuolization is the formation of vacuoles within or adjacent to cells, and, in dermatopathology, often refers to the basal cell-basement membrane zone area.[1]

Perinuclear vacuolization of epidermal keratinocytes.
Subnuclear vacuolization in palisading cell - vacuoles at the basement membrane aspect, resembling a brighter stripe in the periphery of palisades.

It is a feature of koilocytosis, which may be present in potentially precancerous cervical, oral and anal lesions.[2]

See also

References
  1. Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. Page 1230. ISBN 0-7216-0187-1.
  2. Krawczyk E, Suprynowicz FA, Liu X, et al. (September 2008). "Koilocytosis: a cooperative interaction between the human papillomavirus E5 and E6 oncoproteins". Am. J. Pathol. 173 (3): 682–8. doi:10.2353/ajpath.2008.080280. PMC 2527066. PMID 18688031.


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