Vacuolar interface dermatitis

Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis.[1] This change is frequently found in lupus erythematosus, erythema multiforme and lichen sclerosis.

Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain.

References
  1. Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. p. 11. ISBN 1-4160-2999-0.


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