Tutin (toxin)

Tutin is a poisonous plant derivative found in New Zealand tutu plants (several species in the genus Coriaria). It acts as a potent antagonist of the glycine receptor,[1] and has powerful convulsant effects.[2] It is used in scientific research into the glycine receptor. It is sometimes associated with outbreaks of toxic honey poisoning when bees feed on honeydew exudate from the sap-sucking passionvine hopper (Scolypopa australis) insect, when the vine hoppers have been feeding on the sap of tutu bushes. Toxic honey is a rare event and is more likely to occur when comb honey is eaten directly from a hive that has been harvesting honeydew from passionvine hoppers feeding on tutu plants.[3]

Tutin
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.236.780
Chemical and physical data
FormulaC15H18O6
Molar mass294.299 g/mol g·mol−1
3D model (JSmol)
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References

  1. Fuentealba J, Guzmán L, Manríquez-Navarro P, Pérez C, Silva M, Becerra J, Aguayo LG (March 2007). "Inhibitory effects of tutin on glycine receptors in spinal neurons". European Journal of Pharmacology. 559 (1): 61–4. doi:10.1016/j.ejphar.2006.12.018. PMID 17303114.
  2. Zhou H, Tang YH, Zheng Y (May 2006). "A new rat model of acute seizures induced by tutin". Brain Research. 1092 (1): 207–13. doi:10.1016/j.brainres.2006.03.081. PMID 16674929.
  3. Background on toxic honey. New Zealand Food Safety Authority.
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