Trichoepithelioma

Trichoepithelioma
Other names	Brooke's tumour Epithelioma afenoides cysticum .
	Micrograph of a trichoepithelioma. H&E stain.
Specialty	Dermatology
Usual onset	usually young adults
Diagnostic method	Clinical history and examination are important. In a significant number of patients there is a familial trait. Examination will white, translucent, slightly raised papules which have a pearly white appearance.
Treatment	Any suspicicion of malignant change calls for adequate excision and histological examination . The only other reason for treatment is cosmetic . Partial destruction is usally followed by regrowth . Many treatment modalities may be used including surgical excision , curettage , cryotherapy and dermabrasion . High energy pulsed carbon dioxide laser has also been advocated as a useful treatment .

Trichoepithelioma is a neoplasm of the adnexa of the skin.[1] Its appearance is similar to basal cell carcinoma.

One form has been mapped to chromosome 9p21.[2]

Types

Trichoepitheliomas may be divided into the following types:[3]^:672

Pathology

Trichoepitheliomas consisted of nests of basaloid cells. They lack the myxoid stroma and artefactual clefting seen in basal cell carcinoma. Mitoses are uncommon when compared to basal cell carcinoma.

Diagnosis

References

"Trichoepithelioma: Overview - eMedicine Dermatology". Retrieved 2009-02-11.
Salhi A, Bornholdt D, Oeffner F, et al. (August 2004). "Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res. 64 (15): 5113–7. doi:10.1158/0008-5472.CAN-04-0307. PMID 15289313.
James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.

External links

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[urlTrichoepithelioma:_Overview_-_eMedicine_Dermatology-1] "Trichoepithelioma: Overview - eMedicine Dermatology". Retrieved 2009-02-11.

[pmid15289313-2] Salhi A, Bornholdt D, Oeffner F, et al. (August 2004). "Multiple familial trichoepithelioma caused by mutations in the cylindromatosis tumor suppressor gene". Cancer Res. 64 (15): 5113–7. doi:10.1158/0008-5472.CAN-04-0307. PMID 15289313.

[Andrews-3] James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.