Tremorine

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs.[1][2][3][4][5] Beta blockers are also effective in counteracting the effects of tremorine.[6]

Tremorine
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H20N2
Molar mass192.300 g·mol−1
3D model (JSmol)

References
  1. Trautner, E. M.; Gershon, S. (1959). "Use of 'Tremorine' for screening Anti-Parkinsonian Drugs". Nature. 183 (4673): 1462–1463. doi:10.1038/1831462a0. PMID 13657170.
  2. Friedman, A. H.; Aylesworth, R. J.; Friedman, G. (1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science. 141 (3586): 1188–1190. doi:10.1126/science.141.3586.1188. PMID 14043364.
  3. Menon, M.; Clark, W. G.; Aures, D. (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications. 3 (4): 345. doi:10.1016/0031-6989(71)90005-1.
  4. Shinozaki, H.; Hirate, K.; Ishida, M. (1985). "Further studies on quantification of drug-induced tremor in mice: Effects of antitremorgenic agents on tremor frequency". Experimental Neurology. 88 (2): 303–315. doi:10.1016/0014-4886(85)90193-1. PMID 3987859.
  5. Morais, L.; Quintansjunior, L.; Franco, C.; Almeida, J.; Almeida, R. (2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology Biochemistry and Behavior. 79 (4): 745–749. doi:10.1016/j.pbb.2004.10.004. PMID 15582683.
  6. Paul, V. (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: Antitremor effect of beta-adrenoceptor antagonists". Indian Journal of Physiology and Pharmacology. 30 (4): 307–312. PMID 2883120.

See also
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