Treatments for PTSD

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that can develop in certain individuals after exposure to traumatic events, such as combat and sexual assault. PTSD is commonly treated with various types of psychotherapy and pharmacotherapy.

Treatments for PTSD
Specialtypsychiatry

Psychotherapy

Various practitioners have developed integrated programs of treatment that incorporate different psychotherapy techniques.

Techniques

Exposure therapy

Exposure therapy involves exposing the patient to PTSD-anxiety triggering stimuli, with the aim of weakening the neural connections between triggers and trauma memories (aka desensitisation).

Forms include:

  • Flooding – exposing the patient directly to a triggering stimulus, while simultaneously making them not feel afraid.
  • Systematic desensitisation (aka "graduated exposure") – gradually exposing the patient to increasingly vivid experiences that are related to the trauma, but don't trigger post-traumatic stress.

Exposure may involve a real life trigger ("in vivo"), an imagined trigger ("imaginal"), or a triggered feeling generated in a physical way ("interoceptive").[1]

Researchers began experimenting with virtual reality therapy in PTSD exposure therapy in 1997 with the advent of the "Virtual Vietnam" scenario. Virtual Vietnam was used as a graduated exposure therapy treatment for Vietnam veterans meeting the qualification criteria for PTSD. A 50-year-old Caucasian male was the first veteran studied. The preliminary results concluded improvement post-treatment across all measures of PTSD and maintenance of the gains at the six-month follow up. Subsequent open clinical trial of Virtual Vietnam using 16 veterans, showed a reduction in PTSD symptoms.[2]

Cognitive behavioural therapy

Cognitive behavioural therapy focuses on the relationship between someone's thoughts, feelings, and behaviours. It helps people to understand the discrete nature of their thoughts and feelings, and to be better able to control and relate to them.

It is strongly recommended for treatment of PTSD by the American Psychological Association.[3]

Cognitive therapy

Cognitive therapy involves the therapist helping the patient develop and believe a new, less threatening understanding of their trauma experiences.

In one example of the specific practice of imagery rescripting, an adult patient who had a childhood trauma is encouraged to imagine the trauma experience from the point of view of an adult entering the room during the trauma and rescuing and protecting a vulnerable child.

Imagery rehearsal therapy helps people with nightmares. They document their nightmares, then work out how they would like them to change. They then regularly act out the improved dream scenarios.

Cognitive therapy is strongly recommended for treatment of PTSD by the American Psychological Association.[4]

Narrative exposure therapy

Narrative exposure therapy creates a written account of the traumatic experiences of a patient or group of patients, in a way that serves to recapture their self-respect and acknowledges their value. Under this name it is used mainly with refugees, in groups.[5] It also forms an important part of cognitive processing therapy.

It is conditionally recommended for treatment of PTSD by the American Psychological Association.[5]

Relaxation techniques

Relaxation techniques may be the earliest behavioural treatment for PTSD[6], and are often included as part of PTSD treatment.

Integrated programs

Prolonged exposure therapy

Prolonged exposure therapy (PE) was developed by Edna Foa and Micheal Kozak from 1986. It has been extensively tested in clinical trials. While, as the name suggests, it includes exposure therapy, it also includes other psychotherapy elements. Foa believes this therapy to incorporate all the efficacious elements of other known PTSD cognitive therapies. Foa was chair of the PTSD work group of the DSM-IV.

In prolonged exposure therapy, there will most likely be from 8 to 15 sessions. Patients will first be exposed to a past traumatic memory; following is an immediate discussion about the traumatic memory and, "in vivo exposure to safe, but trauma-related, situations that the client fears and avoids".[7]

Slowed breathing techniques and educational information is also touched on in these sessions.

PE is theoretically grounded in emotional processing theory, which states that PTSD symptoms are perpetuated by avoidance of trauma-related stimuli.[8] The goal of this therapy is "to reduce their emotional impact in terms of cognitive (thoughts), behavioral (behavior), or physiological effects (physical)".[9]

It is strongly recommended for treatment of PTSD by the American Psychological Association.[10]

Cognitive processing therapy

Cognitive processing therapy (CPT) was developed by Patricia Resick to treat PTSD in rape victims from 1988.[11][12] Clients write about their traumatic or scary memories in detail, and then read these memories to themselves daily and aloud in therapy sessions. This typically involves twelve sessions with a practitioner.[7] CPT draws on CBT, exposure therapy, narrative exposure therapy and information processing theory.

It is strongly recommended for treatment of PTSD by the American Psychological Association.[13]

Eye movement desensitization and reprocessing

Eye movement desensitization and reprocessing (EMDR) was developed by Francine Shapiro from 1988. It involves a patient thinking of upsetting images while they track a therapist moving their fingers back and forth in front of the patient. Patients are also asked to think of positive thoughts while they follow the fingers back and forth, then they write down what they are thinking.[7] This treatment is found to be similarly effective as exposure therapy.

A proposed neurophysiological basis behind EMDR is that it mimics REM sleep, which plays a vital role in memory consolidation. Imaging studies suggest that "eye movements in both REM sleep and wakefulness activate similar cortical areas."[14] Thus, the reorientation facilitated by EMDR "shifts the brain into a memory processing mode" without "integration of traumatic memories into associative cortical networks without interference from hippocampally mediated episodic recall."[14] The information can then be integrated completely, which consequently weakens the episodic memory of the event and the associations it produced. The restoration of the pathway can lead to recovery from PTSD.

EMDR for PTSD is supported by moderate quality evidence as of 2018.[15]

It is conditionally recommended for treatment of PTSD by the American Psychological Association.[16]

Brief eclectic psychotherapy

Brief eclectic psychotherapy for PTSD (BEPP) was developed by Berthold Gersons and Ingrid Carlier from 1994. It has an emphasis on the emotions of shame and guilt. It involves the patient creating a detailed account of the primary trauma experience (narrative exposure therapy) and writing a letter to person or organisation believed to be most responsible for the trauma. This occurs over sixteen sessions.[17]

It is conditionally recommended for treatment of PTSD by the American Psychological Association.[18]

Trauma-focused cognitive behavioral therapy

Trauma-focused cognitive behavioral therapy (TF-CBT) was developed by Anthony Mannarino, Judith Cohen and Esther Deblinger to help children and adolescents with PTSD. This was done from the mid 1990's.

It involves working through memories of the trauma in a safe and structured environment, trying to change unhelpful beliefs and thoughts, and gradual exposure to triggers which are being avoided. It's held over 8–25 sessions with the child/adolescent and caregiver.

Stress inoculation training

Stress inoculation training was developed to reduce anxiety in doctors during times of intense stress by Donald Meichenbaum from 1985.[19] It is a package of techniques (relaxation, thought stopping and real-life exposure to feared situations) that has been used in PTSD treatment.[6]

Medication

There are many different therapies such as drug therapy, known as pharmacotherapy, is widely used as a treatment for PTSD. Drug therapy is considered less time consuming and easier to continue than psychotherapy (talk therapy). The only two medications for PTSD that are approved by the FDA are sertraline and paroxetine, both antidepressants of the selective serotonin reuptake inhibitors (SSRI) class.[20]

Medication is conditionally recommended for treatment of PTSD by the American Psychological Association.[21]

Antidepressants

Antidepressants are widely used in the treatment of PTSD and have consistently shown efficacy, though the magnitude of improvement is often modest. The most popular types of antidepressants are SSRIs, atypical antidepressants, tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs).[20] SSRI are most often used as they are considered safer than TCAs and MAOIs.[22] To date, only sertraline and paroxetine carry FDA approval for PTSD, though in general, all SSRIs seem similarly effective. These medications appear to be helpful across all PTSD symptoms.[23] According to the APA Practice Guidelines, "SSRIs have proven efficacy for PTSD symptoms and related functional problems".[24]

Other medications

Prazosin, an alpha-adrenoceptor antagonist, is also widely prescribed, particularly for sleep-related symptoms. Early studies had shown evidence of efficacy,[20] though a recent relatively large trial failed to show a statistically significant difference between prazosin and placebo.[25] Antipsychotic medications have also been prescribed to treat PTSD, though clinical trials have not yielded consistent evidence for their efficacy.[20]

Alternative, complementary, and non-traditional treatment

Alternative medicine is any practice that is put forward as having the healing effects of medicine.[26][27] Its characteristics are that it does not originate from evidence gathered using the scientific method, is not part of biomedicine, and is contradicted by scientific evidence or established science.[26][27] Over the last decade, alternative treatment has become increasingly common in treating veterans with post-traumatic stress disorder. It is often used selectively in clinical trials. While it is not yet accepted medical treatment, there are often studies being done to test its effectiveness. Usually, it is used as a last resort due to the failure of conventional treatment.

Yoga therapy treatment

Yoga may be useful as a treatment for PTSD, but the evidence for this is weak.[28]

Trauma group therapy

In trauma group therapy, the groups range from 12 to 18 members and are completed over a 10- to 12-week period. Group therapy is cost-effective, and allows the participant to know they are not alone which can help in building another support system beside their family, and help in the development of people skills (communication, adversity, and confidence).[29] Group cognitive behavioral therapy is based on participants connecting and sharing past experiences while developing trust. Since World War II, the method of having soldiers come together and converse amongst each other has been in practice.[30] Patients remember and examine their war experiences and are encouraged to provide a clear picture without hiding or omitting details.[31] In “A Meta-Analytic Review of Exposure in Group Cognitive Behavioral Therapy for Posttraumatic Stress Disorder,” written by Barrera, she mentions that there are some three concerns with group therapy. Barrera mentions that members in the group can develop secondary post-traumatic stress disorder from hearing others traumatic events and that one participant may think their traumatic event is not comparable to another member’s event. These concerns can cause a delay in recovery, and there may not be enough time in a session for participants to talk about their experiences.[29]

Animal-assisted therapy

Clinicians can recommend animal-assisted therapy (AAT) to PTSD-affected patients when there are issues of isolation, anger management, and difficulty with social interactions.[32] AAT consists of a treatment plan of human-animal therapy interaction. Animals, like dogs, typically interact with individuals or groups who have anxiety, schizophrenia, addiction, and depression. Hospitalized patients are often the most likely candidates for animal-assisted therapy, but AAT can also help people in personal homes, schools, community centers, nursing homes, or rehabilitation centers. “Interaction with the  animals... decrease[s] blood pressure and to have a calming effect on individuals with dissociative disorder.”[32] AAT can also reduce anger and stress. AAT is often overlooked or not considered within PTSD patients treatment options.

Present centered therapy

Present centered therapy (PCT) is a non-trauma-focused, evidence-based psychotherapy (EBP) for PTSD. According to VA/DOD PTSD treatment guidelines (2015), it is currently a second-line recommended treatment (i.e., “weak-for”) for PTSD. [33]

Other interpersonal psychotherapy approaches

Other approaches, in particular involving social supports,[34][35] may also be important. An open trial of interpersonal psychotherapy[36] reported high rates of remission from PTSD symptoms without using exposure.[37] A current, NIMH-funded trial in New York City is now (and into 2013) comparing interpersonal psychotherapy, prolonged exposure therapy, and relaxation therapy.[38][39][40]

Benzodiazepines

Benzodiazepines are not recommended for the treatment of PTSD due to a lack of evidence of benefit and risk of worsening PTSD symptoms.[41] Some authors believe that the use of benzodiazepines is contraindicated for acute stress, as this group of drugs can cause dissociation.[42] Nevertheless, some use benzodiazepines with caution for short-term anxiety and insomnia.[43][44][45] While benzodiazepines can alleviate acute anxiety, there is no consistent evidence that they can stop the development of PTSD and may actually increase the risk of developing PTSD 2–5 times.[46] Additionally, benzodiazepines may reduce the effectiveness of psychotherapeutic interventions, and there is some evidence that benzodiazepines may actually contribute to the development and chronification of PTSD. For those who already have PTSD, benzodiazepines may worsen and prolong the course of illness, by worsening psychotherapy outcomes, and causing or exacerbating aggression, depression (including suicidality), and substance use.[46] Drawbacks include the risk of developing a benzodiazepine dependence, tolerance (i.e., short-term benefits wearing off with time), and withdrawal syndrome; additionally, individuals with PTSD (even those without a history of alcohol or drug misuse) are at an increased risk of abusing benzodiazepines.[47][48] Due to a number of other treatments with greater efficacy for PTSD and less risks (e.g., prolonged exposure, cognitive processing therapy, eye movement desensitization and reprocessing, cognitive restructuring therapy, trauma-focused cognitive behavioral therapy, brief eclectic psychotherapy, narrative therapy, stress inoculation training, serotonergic antidepressants, adrenergic inhibitors, antipsychotics, and even anticonvulsants), benzodiazepines should be considered relatively contraindicated until all other treatment options are exhausted.[49][50] For those who argue that benzodiazepines should be used sooner in the most severe cases, the adverse risk of disinhibition (associated with suicidality, aggression and crimes) and clinical risks of delaying or inhibiting definitive efficacious treatments, make other alternative treatments preferable (e.g., inpatient, residential, partial hospitalization, intensive outpatient, dialectic behavior therapy; and other fast-acting sedating medications such as trazodone, mirtazapine, amitripytline, doxepin, prazosin, propranolol, guanfacine, clonidine, quetiapine, olanzapine, valproate, gabapentin).[47][50][51]

Glucocorticoids

Glucocorticoids may be useful for short-term therapy to protect against neurodegeneration caused by the extended stress response that characterizes PTSD, but long-term use may actually promote neurodegeneration.[52]

Cannabinoids

As of 2019 cannabis is specifically not recommended as a treatment.[53][54] However, use of cannabis or derived products is widespread among U.S. veterans with PTSD.[55]

The cannabinoid nabilone is sometimes used for nightmares in PTSD. Although some short-term benefit was shown, adverse effects are common and it has not been adequately studied to determine efficacy.[56] Currently, a handful of states permit the use of medical cannabis for the treatment of PTSD.[57]

MDMA

Carefully administered MDMA has been used, in conjunction with psychotherapy, to treat PTSD.[58]

Multicultural perspectives

Trauma is ingrained in culture, and different cultures receive and treat trauma in different ways.[59] Some cultures treat trauma with ancient practices such as praying or ritual.[59]

Historical trauma is defined as traumatic stressors resulting from historical events that affect indigenous and First Nation communities. Many therapists use cultural intervention, the practice of culture, a sense of belonging and having a purpose and "a return to indigenous traditional practices" as a form of treatment for HT.[60] This works by not making First Nation individuals adapt to the problems that result from historical trauma, or by First Nation individuals trying to change the way they think, “but rather spiritual transformations and accompanying shifts in collective identity, purpose, and meaning making.”[60] Many Indigenous and First Nations communities developed HT as a result of forced European colonization beginning in the 15th century. HT came about during the colonial era and is ongoing. HT is often overlooked due to mental health professionals working under the impression that PTSD symptoms are as equivalent to those that undergo historical trauma. HT is often misunderstood by some mental health professionals because these only focus on the individual, not historical causes and events.

Researchers at the Stress-response Syndromes Lab at the University of Zurich, Switzerland, use the historical contributions of the Swiss psychologist Carl Gustav Jung to develop culturally sensitive treatments like symbolism and different myth stories to treat PTSD. Jung’s psychology asserts that “the fundamental ‘language’ of the psyche is not words, but images...studying the trinity of myths, metaphors, and archetypes enhances clinical interventions and psychotherapy.”[61]

A combination of Western psychotherapy and Japanese culture is helpful when using psychotherapy as an effective treatment in Japan.[62] "After the Kobe-Awaji earthquake in 1995...Japanese psychologists became acutely aware of the need to receive specialized training in the treatment of posttraumatic stress disorder (PTSD) as well as crisis intervention."[62] Psychotherapy is a recent practice used in Japan in which some practices of western psychotherapy are “modified to suit the Japanese client population” and forms to create a sense of cultural integration.[62] The  two main methods of treatment practices Japanese psychotherapists work with are nonverbal tasks and parallel therapy.

Recommendations

A number of major health bodies have developed lists of treatment recommendations. These include:

References
  1. "What Is Exposure Therapy?".
  2. Rizzo AA, Rothbaum BO, Graap K. Virtual reality applications for combat-related posttraumatic stress disorder. In: Figley CR, Nash WP, editors. Combat stress injury: Theory, research and management. New York: Routledge; 2007. pp. 420–425
  3. "Cognitive Behavioral Therapy (CBT) for Treatment of PTSD".
  4. "Cognitive Therapy (CT)".
  5. "Narrative Exposure Therapy (NET)".
  6. Sharpless, Brian A.; Barber, Jacques P. (February 1, 2011). "A Clinician's Guide to PTSD Treatments for Returning Veterans". Professional Psychology: Research and Practice. 42 (1): 8–15. doi:10.1037/a0022351. PMC 3070301. PMID 21475611.
  7. Sharpless BA Barber JP (2011). "A clinician's guide to PTSD treatments for returning veterans". Professional Psychology: Research and Practice. 42 (1): 8–15. doi:10.1037/a0022351. PMC 3070301. PMID 21475611.
  8. Foa, Edna B. (December 2011). "Prolonged exposure therapy: past, present, and future". Depression and Anxiety. 28 (12): 1043–1047. doi:10.1002/da.20907. PMID 22134957.
  9. Carlson JG Chemtob CM Rusnak K Hedlund NL (1996). "Eye movement desensitization and reprocessing treatment for combat PTSD". Psychotherapy: Theory, Research, Practice, Training. 33 (1): 104–113. doi:10.1037/0033-3204.33.1.104.
  10. "Prolonged Exposure (PE)".
  11. "About Us | Cognitive Processing Therapy".
  12. Resick, Patricia A.; Schnicke, Monica (1993). Cognitive Processing Therapy for Rape Victims: A Treatment Manual. Sage Publications. ISBN 978-0-8039-4902-7.
  13. "Cognitive Processing Therapy (CPT)".
  14. Stickgold, Roger (January 2002). "EMDR: A putative neurobiological mechanism of action". Journal of Clinical Psychology. 58 (1): 61–75. CiteSeerX 10.1.1.124.5340. doi:10.1002/jclp.1129. PMID 11748597.
  15. Forman-Hoffman, Valerie; Middleton, Jennifer Cook; Feltner, Cynthia; Gaynes, Bradley N.; Weber, Rachel Palmieri; Bann, Carla; Viswanathan, Meera; Lohr, Kathleen N.; Baker, Claire; Green, Joshua (May 2018). "Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder: A Systematic Review Update". Comparative Effectiveness Review. AHRQ Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality (US). PMID 30204376.
  16. "Eye Movement Desensitization and Reprocessing (EMDR) Therapy".
  17. "Information". Traumabehandeling. March 31, 2017.
  18. https://www.apa.org/ptsd-guideline/treatments/brief-eclectic-psychotherapy
  19. "PsycNET". psycnet.apa.org.
  20. Abdallah, Chadi G.; Averill, Lynnette A.; Akiki, Teddy J.; Raza, Mohsin; Averill, Christopher L.; Gomaa, Hassaan; Adikey, Archana; Krystal, John H. (14 September 2018). "The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder". Annual Review of Pharmacology and Toxicology. 59 (1): 171–189. doi:10.1146/annurev-pharmtox-010818-021701. PMC 6326888. PMID 30216745.
  21. "Medications".
  22. Giller, EL (ed.) (1990). Biological Assessment and Treatment of Posttraumatic Stress Disorder. Washington DC: American Psychiatric Press, Inc.CS1 maint: extra text: authors list (link)
  23. "Clinician's Guide to Medications for PTSD". U.S. Department of Veterans Affairs. 2009.
  24. American Psychiatric Association. Practice Guideline for the Treatment of Patients With Acute Stress Disorder and Posttraumatic Stress Disorder. doi:10.1176/appi.books.9780890423363.52257
  25. Raskind, Murray A.; Peskind, Elaine R.; Chow, Bruce; Harris, Crystal; Davis-Karim, Anne; Holmes, Hollie A.; Hart, Kimberly L.; McFall, Miles; Mellman, Thomas A.; Reist, Christopher; Romesser, Jennifer; Rosenheck, Robert; Shih, Mei-Chiung; Stein, Murray B.; Swift, Robert; Gleason, Theresa; Lu, Ying; Huang, Grant D. (8 February 2018). "Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans". New England Journal of Medicine. 378 (6): 507–517. doi:10.1056/NEJMoa1507598. PMID 29414272.
  26. Marcinko, David Edward; Hetico, Hope Rachel (2016-01-06). Risk Management, Liability Insurance, and Asset Protection Strategies for Doctors and Advisors: Best Practices from Leading Consultants and Certified Medical PlannersTM. CRC Press. ISBN 9781498725996.
  27. Coulter, Ian D.; Willis, Evan M. (2004-01-01). "The rise and rise of complementary and alternative medicine: a sociological perspective". Medical Journal of Australia. 180 (11). ISSN 0025-729X.
  28. Gallegos AM, Crean HF, Pigeon WR, Heffner KL (December 2017). "Meditation and yoga for posttraumatic stress disorder: A meta-analytic review of randomized controlled trials". Clin Psychol Rev. 58: 115–124. doi:10.1016/j.cpr.2017.10.004. PMC 5939561. PMID 29100863.
  29. Barrera, T (2013). "A Meta-Analytic Review of Exposure in Group Cognitive Behavioral Therapy for Posttraumatic Stress Disorder". Clinical Psychology Review. PubMed. 33 (1): 24–32. doi:10.1016/j.cpr.2012.09.005. PMID 23123568.
  30. Kingsley, G. "Contemporary Group Treatment of Combat-Related Posttraumatic Stress Disorder". ProQuest. ProQuest 198124994. Missing or empty |url= (help)
  31. Rozynko V Dondershine HE (1991). "Trauma focus group therapy for Vietnam veterans with PTSD". Psychotherapy: Theory, Research, Practice, Training. 28 (1): 157–161. doi:10.1037/0033-3204.28.1.157.
  32. Wynn, Gary H. (Aug 2015). "Complementary and Alternative Medicine Approaches in the Treatment of PTSD". Curr Psychiatry Rep. 17: 1–7 – via Springer.
  33. Frost et al. 2014 ITSDD
  34. Brewin CR, Andrews B, Valentine JD (October 2000). "Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults". Journal of Consulting and Clinical Psychology. 68 (5): 748–66. doi:10.1037/0022-006X.68.5.748. PMID 11068961.
  35. Ozer EJ, Best SR, Lipsey TL, Weiss DS (January 2003). "Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis". Psychological Bulletin. 129 (1): 52–73. doi:10.1037/0033-2909.129.1.52. PMID 12555794.
  36. Weissman MM, Markowitz JC, Klerman GL (2007). Clinician's Quick Guide to Interpersonal Psychotherapy. New York: Oxford University Press.
  37. Bleiberg KL, Markowitz JC (January 2005). "A pilot study of interpersonal psychotherapy for posttraumatic stress disorder". The American Journal of Psychiatry. 162 (1): 181–3. doi:10.1176/appi.ajp.162.1.181. PMID 15625219.
  38. "Trauma and PTSD Program – Columbia University Department of Psychiatry". Columbiatrauma.org. Archived from the original on 2014-02-01. Retrieved 2014-01-29.
  39. Markowitz JC, Milrod B, Bleiberg K, Marshall RD (March 2009). "Interpersonal factors in understanding and treating posttraumatic stress disorder". Journal of Psychiatric Practice. 15 (2): 133–40. doi:10.1097/01.pra.0000348366.34419.28. PMC 2852131. PMID 19339847.
  40. Markowitz JC (October 2010). "IPT and PTSD". Depression and Anxiety. 27 (10): 879–81. doi:10.1002/da.20752. PMC 3683871. PMID 20886608.
  41. Jain S, Greenbaum MA, Rosen C (February 2012). "Concordance between psychotropic prescribing for veterans with PTSD and clinical practice guidelines". Psychiatric Services. 63 (2): 154–60. doi:10.1176/appi.ps.201100199. PMID 22302333.
  42. Auxéméry Y (October 2012). "[Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context]". L'Encephale (in French). 38 (5): 373–80. doi:10.1016/j.encep.2011.12.003. PMID 23062450.
  43. Kapfhammer HP (December 2008). "[Therapeutic possibilities after traumatic experiences]". Psychiatria Danubina. 20 (4): 532–45. PMID 19011595.
  44. Reist, C (2005). Post-traumatic Stress Disorder. Compendia, Build ID: F000005, published by Epocrates.com
  45. Maxmen JS, Ward NG (2002). Psychotropic drugs: fast facts (3rd ed.). New York: W. W. Norton. p. 349. ISBN 978-0-393-70301-6.
  46. Guina J, Rossetter SR, DeRHODES BJ, Nahhas RW, Welton RS (July 2015). "Benzodiazepines for PTSD: A Systematic Review and Meta-Analysis". Journal of Psychiatric Practice. 21 (4): 281–303. doi:10.1097/pra.0000000000000091. PMID 26164054.
  47. Berger W, Mendlowicz MV, Marques-Portella C, Kinrys G, Fontenelle LF, Marmar CR, Figueira I (March 2009). "Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33 (2): 169–80. doi:10.1016/j.pnpbp.2008.12.004. PMC 2720612. PMID 19141307.
  48. Martényi F (March 2005). "[Three paradigms in the treatment of posttraumatic stress disorder]". Neuropsychopharmacologia Hungarica. 7 (1): 11–21. PMID 16167463.
  49. Haagen JF, Smid GE, Knipscheer JW, Kleber RJ (August 2015). "The efficacy of recommended treatments for veterans with PTSD: A metaregression analysis". Clinical Psychology Review. 40: 184–94. doi:10.1016/j.cpr.2015.06.008. PMID 26164548.
  50. Veterans Affairs and Department of Defense clinical practice guideline for management of post-traumatic stress. VA/DoD. 2010.
  51. Bandelow B, Zohar J, Hollander E, Kasper S, Möller HJ, Zohar J, Hollander E, Kasper S, Möller HJ, Bandelow B, Allgulander C, Ayuso-Gutierrez J, Baldwin DS, Buenvicius R, Cassano G, Fineberg N, Gabriels L, Hindmarch I, Kaiya H, Klein DF, Lader M, Lecrubier Y, Lépine JP, Liebowitz MR, Lopez-Ibor JJ, Marazziti D, Miguel EC, Oh KS, Preter M, Rupprecht R, Sato M, Starcevic V, Stein DJ, van Ameringen M, Vega J (2008). "World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders – first revision". The World Journal of Biological Psychiatry. 9 (4): 248–312. doi:10.1080/15622970802465807. PMID 18949648.
  52. Griffin GD, Charron D, Al-Daccak R (November 2014). "Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis". Clinical & Translational Immunology. 3 (11): e27. doi:10.1038/cti.2014.26. PMC 4255796. PMID 25505957.
  53. Black, Nicola; Stockings, Emily; Campbell, Gabrielle; Tran, Lucy T; Zagic, Dino; Hall, Wayne D; Farrell, Michael; Degenhardt, Louisa (October 2019). "Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis". The Lancet Psychiatry. 6 (12): 995–1010. doi:10.1016/S2215-0366(19)30401-8. PMID 31672337.
  54. O'Neil ME, Nugent SM, Morasco BJ, Freeman M, Low A, Kondo K, Zakher B, Elven C, Motu'apuaka M, Paynter R, Kansagara D (September 2017). "Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review". Annals of Internal Medicine. 167 (5): 332–340. doi:10.7326/M17-0477. PMID 28806794.
  55. Betthauser K, Pilz J, Vollmer LE (August 2015). "Use and effects of cannabinoids in military veterans with posttraumatic stress disorder". American Journal of Health-System Pharmacy (Review). 72 (15): 1279–84. doi:10.2146/ajhp140523. PMID 26195653.
  56. "Long-term Nabilone Use: A Review of the Clinical Effectiveness and Safety". CADTH Rapid Response Reports. Oct 2015. PMID 26561692.
  57. Gregg K (2016-07-13). "Raimondo signs law allowing marijuana for treatment of PTSD". Providence Journal. Archived from the original on 16 August 2016. Retrieved 18 August 2016.
  58. "MDMA and PTSD - Alcohol and Drug Foundation".
  59. Wilson, John (2002). "The Lens of Culture: Theoretical and Conceptual Perspectives in the Assessment of Psychological Trauma and PTSD". The Lens of Culture. WHO Publication. pp. 3–30.
  60. Gone, Joseph P. (2013). "Redressing First Nations historical trauma: Theorizing mechanisms for indigenous culture as mental health treatment". Transcultural Psychiatry. 50 (5): 683–706. doi:10.1177/1363461513487669. PMID 23715822.
  61. Maercker, Andrea and Heim, Eva (Summer 2016). "A New Approach to Culturally Sensitive PTSD Research in Zurich – Inspired by Contributions from Cal Gustav Jung". International Psychology Bulletin. 20 (3): 67–71.CS1 maint: multiple names: authors list (link)
  62. Iwakabe, Shigeru (2008). "Psychotherapy Integration in Japan". Journal of Psychotherapy Integration, Ochanomizu University. 18 (1): 103–125. doi:10.1037/1053-0479.18.1.103.
  63. https://www.apa.org/ptsd-guideline/treatments/
  64. "Treatment Essentials - PTSD: National Center for PTSD".
  65. "Recommendations | Post-traumatic stress disorder | Guidance | NICE".
  66. "Australian PTSD Guidelines".
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.