Tofogliflozin
Tofogliflozin (INN,[1]:88 USAN, codenamed CSG452) is an experimental drug for the treatment of diabetes mellitus and is being developed by Chugai Pharma in collaboration with Kowa and Sanofi.[2] It is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. As of September 2012, the drug is in Phase III clinical trials.[3][4]
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Other names | CSG452 |
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Formula | C22H28O7 |
Molar mass | 404.45 g/mol g·mol−1 |
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Chemistry
The active moiety or anhydrous form (ChemSpider ID: 28530778, CHEMBL2110731) has the chemical formula C22H26O6 and a molecular mass of 386.44 g/mol.
The United States Adopted Name tofogliflozin applies to the monohydrate, which is the form used as a drug.[5] The International Nonproprietary Name tofogliflozin applies to the anhydrous compound[1] and the drug form is referred to as tofogliflozin hydrate.
See also
References
- "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 65" (PDF). World Health Organization. Retrieved 15 November 2016.
- Chugai Pharmaceutical: Development Pipeline
- Nagata, T.; Fukazawa, M.; Honda, K.; Yata, T.; Kawai, M.; Yamane, M.; Murao, N.; Yamaguchi, K.; Kato, M.; Mitsui, T.; Suzuki, Y.; Ikeda, S.; Kawabe, Y. (2012). "Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats". AJP: Endocrinology and Metabolism. 304 (4): E414–E423. doi:10.1152/ajpendo.00545.2012. PMID 23249697.
- Ohtake, Y.; Sato, T.; Kobayashi, T.; Nishimoto, M.; Taka, N.; Takano, K.; Yamamoto, K.; Ohmori, M.; Yamaguchi, M.; Takami, K.; Yeu, S. Y.; Ahn, K. H.; Matsuoka, H.; Morikawa, K.; Suzuki, M.; Hagita, H.; Ozawa, K.; Yamaguchi, K.; Kato, M.; Ikeda, S. (2012). "Discovery of Tofogliflozin, a NovelC-Arylglucoside with anO-Spiroketal Ring System, as a Highly Selective Sodium Glucose Cotransporter 2 (SGLT2) Inhibitor for the Treatment of Type 2 Diabetes". Journal of Medicinal Chemistry. 55 (17): 7828–7840. doi:10.1021/jm300884k. PMID 22889351.
- Statement on a nonproprietary name adopted by the USAN council: Tofogliflozin.