Tingible body macrophage

A tingible body macrophage is a type of macrophage predominantly found in germinal centers, containing many phagocytized, apoptotic cells in various states of degradation, referred to as tingible bodies (tingible meaning stainable).[1] Tingible body macrophages contain condensed chromatin fragments.[2]

It is thought that they may play a role in downregulating the germinal center reaction by the release of prostaglandins and hence a reduced B-cell induction of IL-2.[3]

Macrophages that contain debris from ingested lymphocytes are characteristic of a reactive follicular center in benign reactive lymphadenitis. Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerous mitotic figures.