Tilmacoxib

Tilmacoxib
Pharmacokinetic data
Bioavailability	solution (64–88%) compared with capsule (22–40%).
Identifiers
	IUPAC name 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide;
PubChem CID	159271;
ChemSpider	140082;
UNII	G6VI5P84SX;
ChEBI	CHEBI:73041 ;
ChEMBL	ChEMBL34913;
CompTox Dashboard (EPA)	DTXSID0057671 ;
Chemical and physical data
Formula	C16H19FN2O3S
Molar mass	338.397 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(N)c3ccc(c1oc(nc1C2CCCCC2)C)cc3F;
	InChI InChI=1S/C16H19FN2O3S/c1-10-19-15(11-5-3-2-4-6-11)16(22-10)12-7-8-14(13(17)9-12)23(18,20)21/h7-9,11H,2-6H2,1H3,(H2,18,20,21); Key:MIMJSJSRRDZIPW-UHFFFAOYSA-N;

Tilmacoxib or JTE-522 is a COX-2 inhibitor and is an effective chemopreventive agent against rat experimental liver fibrosis.[1]

References

Yamamoto, H., Kondo, M., Nakamori, S., Nagano, H., Wakasa, K., Sugita, Y., Chang-De, J., Kobayashi, S., Damdinsuren, B., Dono, K., Umeshita, K., Sekimoto, M., Sakon, M., Matsuura, N., Monden, M. (2003). "JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1". Gastroenterology. 125 (2): 556–571. doi:10.1016/s0016-5085(03)00904-1. PMID 12891558.CS1 maint: multiple names: authors list (link)

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