Thermal amplitude

Thermal amplitude or thermal range refers to the temperature range in which a cold autoantibody or cold-reacting alloantibody binds to its antigen.[1][2] Cold antibodies that can bind to antigen above 30 °C (86 °F) are considered potentially clinically significant and may lead to disease that occurs or worsens on exposure to low temperatures.[2][3] The closer the thermal range comes to core body temperature (37 °C or 99 °F), the greater the chance that the antibody will cause symptoms such as anemia or Raynaud syndrome.[1][3] Antibodies that are only reactive at temperatures below 30 °C (86 °F) are generally considered unlikely to be clinically significant.[1]