Talsupram

Talsupram
Clinical data
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: uncontrolled;
Identifiers
	IUPAC name 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine;
CAS Number	21489-20-3;
PubChem CID	33014;
ChemSpider	30557;
UNII	C6Z73MW6CR;
Chemical and physical data
Formula	C20H25NS
Molar mass	311.48 g/mol g·mol−1

Talsupram (Lu 5-005 or Lu 5-003[1]) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[2][3][4] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[5]

References

Br. J. Pharmac. (1969), 36, 18-28. Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro A. CARLSSON, K. FUXE, B. HAMBERGER AND T. MALMFORS
Pawłowski L, Mazela H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology. 88 (2): 240–6. doi:10.1007/BF00652248. PMID 3006113.
McConathy J, Owens MJ, Kilts CD, et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology. 31 (6): 705–18. doi:10.1016/j.nucmedbio.2003.05.001. PMID 15246361.
Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology. 28 (3): 332–47. doi:10.1016/S0306-4530(02)00026-4. PMID 12573300.
http://www.healyprozac.com/Book/Introduction.doc

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.