T-lymphoblastic leukemia/lymphoma

T-lymphoblastic leukemia/lymphoma (WHO 2008),[1]:219 previously labeled precursor T-lymphoblastic leukemia/lymphoma (WHO 2001)[1]:219 is a form of lymphoid leukemia[2][3] and lymphoma[4] in which too many T-cell lymphoblasts (immature white blood cells) are found in the blood, bone marrow, and tissues, particularly mediastinal lymph nodes.[1]:635 Labeling as leukemia or lymphoma depends on which feature is more pronounced in a given situation, but has no biological or treatment implication.[1]:635

T-lymphoblastic leukemia/lymphoma
Other namesPrecursor T-cell lymphoblastic lymphoma, Precursor T acute lymphoblastic leukemia/lymphoma
SpecialtyHematology, oncology

It is uncommon in adults, but represents 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma.[1]:635

The 2008 terminology dropped "precursor" to avoid linguistic redundancy because the lymphoblast is an immature precursor cell by definition.[1]:219

References
  1. Jaffe ES, Harris NL, Vardiman JW, Campo E, Arber, DA (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
  2. Kim MA, Lee GW, Maeng KY (August 2005). "An unusual presenting feature of precursor T-cell acute lymphoblastic leukemia/lymphoma". Ann. Hematol. 84 (8): 553–4. doi:10.1007/s00277-005-1042-4. PMID 15843931.
  3. Lyman MD, Neuhauser TS (April 2002). "Precursor T-cell acute lymphoblastic leukemia/lymphoma involving the uterine cervix, myometrium, endometrium, and appendix". Ann Diagn Pathol. 6 (2): 125–8. doi:10.1053/adpa.2002.32381. PMID 12004362.
  4. Han X, Bueso-Ramos CE (April 2007). "Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias". Am. J. Clin. Pathol. 127 (4): 528–44. doi:10.1309/2QE3A6EKQ8UYDYRC. PMID 17369128.

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

Classification


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