Supersensitivity psychosis

Supersensitivity psychosis is used to discuss the spontaneous occurrence of psychotic episodes and/or the appearance of tardive dykinesia in the wake of anti-psychotic medication withdrawal.

Such spontaneous episodes have occurred even in patients who never had psychotic episodes before beginning the medication. Studies using clozapine have found significant evidence.

Larger discussions of withdrawal from other antipsychotics usually focus on tardive dyskinesia, a far more significant and long-lasting side effect[1] of antipsychotic treatment.

When supersensitivity psychosis was explored in 1978,[2] a featured concern was increasing resistance to medication, requiring higher doses or not responding to higher doses. Some articles use the term tardive psychosis to reference to this specific concept.[3] However, articles have disputed its validity.[3][4] The condition has been discovered in very few people.[3][5] Palmstierna asserts that tardive psychosis is a combination of "several different and not necessarily correlated phenomena related to neuroleptic treatment of schizophrenia."[6]

However, some articles use the term tardive psychosis as equivalent to supersensitivity psychosis.

See also

Further reading
  • Chouinard G, Jones BD (1980). "Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics". Am J Psychiatry. 137 (1): 16–21. doi:10.1176/ajp.137.1.16. PMID 6101522.
  • Steiner W, Laporta M, Chouinard G (1990). "Neuroleptic-induced supersensitivity psychosis in patients with bipolar affective disorder". Acta Psychiatr Scand. 81 (5): 437–40. doi:10.1111/j.1600-0447.1990.tb05477.x. PMID 1972608.CS1 maint: multiple names: authors list (link)
  • Moncrieff J (2006). "Does antipsychotic withdrawal provoke psychosis? Review of the literature on rapid onset psychosis (supersensitivity psychosis) and withdrawal-related relapse". Acta Psychiatr Scand. 114 (1): 3–13. doi:10.1111/j.1600-0447.2006.00787.x. PMID 16774655.
  • Miller R, Chouinard G (1993). "Loss of striatal cholinergic neurons as a basis for tardive and L-dopa-induced dyskinesias, neuroleptic-induced supersensitivity psychosis and refractory schizophrenia". Biol Psychiatry. 34 (10): 713–38. doi:10.1016/0006-3223(93)90044-e. PMID 7904833.
  • Fallon P, Dursun S, Deakin B (2012). "Drug-induced supersensitivity psychosis revisited: characteristics of relapse in treatment-compliant patients". Ther Adv Psychopharmacol. 2 (1): 13–22. doi:10.1177/2045125311431105. PMC 3736929. PMID 23983951.CS1 maint: multiple names: authors list (link)

References
  1. "What Is Tardive Dyskinesia?"
  2. Chouinard G, Jones BD, Annable L (1978). "Neuroleptic-induced supersensitivity psychosis". Am J Psychiatry. 135 (11): 1409–10. doi:10.1176/ajp.135.11.1409. PMID 30291.CS1 maint: multiple names: authors list (link)
  3. Palmstierna, T; Wistedt, B (1988). "Tardive psychosis: Does it exist?". Psychopharmacology. 94 (1): 144–5. doi:10.1007/BF00735897. PMID 2894699.
  4. Kirkpatrick B, Alphs L, Buchanan RW (1992). "The concept of supersensitivity psychosis". J Nerv Ment Dis. 180 (4): 265–70. doi:10.1097/00005053-199204000-00009. PMID 1348269.CS1 maint: multiple names: authors list (link)
  5. Chouinard G (1991). "Severe cases of neuroleptic-induced supersensitivity psychosis. Diagnostic criteria for the disorder and its treatment". Schizophr Res. 5 (1): 21–33. doi:10.1016/0920-9964(91)90050-2. PMID 1677263.
  6. "Tardive psychosis: does it exist?" (pdf download link)
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