Spinal trigeminal nucleus

The spinal trigeminal nucleus is a nucleus in the medulla that receives information about deep/crude touch, pain, and temperature from the ipsilateral face. In addition to the trigeminal nerve (CN V), the facial (CN VII), glossopharyngeal (CN IX), and vagus nerves (CN X) also convey pain information from their areas to the spinal trigeminal nucleus.[1] Thus the spinal trigeminal nucleus receives input from cranial nerves V, VII, IX, and X.

Spinal trigeminal nucleus
The cranial nerve nuclei schematically represented; dorsal view. Motor nuclei in red; sensory in blue. (Trigeminal nerve nuclei are at "V".)
Horizontal section through the lower part of the pons showing the spinal trigeminal nucleus (#11).
Latinnucleus spinalis nervi trigemini
Anatomical terms of neuroanatomy

The spinal nucleus is composed of three subnuclei: subnucleus oralis (pars oralis), subnucleus caudalis (pars caudalis), and subnucleus interpolaris (pars interpolaris). The subnucleus oralis is associated with the transmission of discriminative (fine) tactile sense from the orofacial region, and is continuous with the principal sensory nucleus of V. The subnucleus interpolaris is also associated with the transmission of tactile sense, as well as dental pain, whereas the subnucleus caudalis is associated with the transmission of nociception and thermal sensations from the head.

This region is also denoted at sp5 in other neuroanatomical nomenclature.[2]

This nucleus projects to the ventral posteriomedial (VPM) nucleus in the contralateral thalamus via the ventral trigeminal tract. In mice, this thalamic nucleus has significant amounts of expression of leptin receptors, NPY and GLP-1.[3]

See also


  1. Brainstem Nuclei Archived 2007-04-13 at the Wayback Machine
  2. George Paxinos (2004). The Mouse Brain in Stereotaxic Coordinates. Gulf Professional Publishing. ISBN 978-0-12-547640-9. Retrieved 16 August 2013.
  3. Mercer, Julian G, Moar, Kim M, Findlay, Patricia A, Hoggard, Nigel, Adam, Clare L (1998). "Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem". Regulatory peptides. Elsevier. 75: 271–278.CS1 maint: multiple names: authors list (link)

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