Slow-reacting substance of anaphylaxis

The slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.

LTC₄

LTD₄

LTE₄

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.

References

"Dorland's Medical Dictionary". Archived from the original on January 9, 2007. Retrieved December 15, 2006.
Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.

External links

Slow+Reacting+Substance+of+Anaphylaxis at the US National Library of Medicine Medical Subject Headings (MeSH)

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[1] "Dorland's Medical Dictionary". Archived from the original on January 9, 2007. Retrieved December 15, 2006.

[2] Howard R. Morris; Graham W. Taylor; Priscilla J. Piper; John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.