SCH-50911
SCH-50911 is a selective GABAB antagonist.[1] Its main applications are in pharmacology research.
Names | |
---|---|
IUPAC name
2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acid | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChemSpider | |
MeSH | SCH-50911 |
PubChem CID |
|
CompTox Dashboard (EPA) |
|
InChI
| |
SMILES
| |
Properties | |
Chemical formula |
C8H15NO3 |
Molar mass | 173.21 g·mol−1 |
Melting point | 154.5 to 157 °C (310.1 to 314.6 °F; 427.6 to 430.1 K) (hydrochloride) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
SCH-50911 also acts as an anticonvulsant under normal conditions. SCH-50911 induces acute withdrawal syndrome in GHB-dependent rats, similar to the delirium tremens seen in human alcohol withdrawal, and can precipitate convulsions in GHB-dependent animals.[2]
References
- Blythin DJ, Kuo SC, Shue HJ, McPhail AT, Chapman RW, Kreutner W, Rizzo C, She HS, West R. Substituted morpholine-2S-acetic acid derivatives: SCH 50911 and Related Compounds as Novel GABAB Antagonists. Bioorganic & Medicinal Chemistry Letters. 1996 Jul 9; 6(13): 1529-1534.
- Quang LS, Colombo G, Lobina C, Maccioni P, Orru A, Gessa GL, Maher TJ, Carai MA. Evaluation for the withdrawal syndrome from gamma-hydroxybutyric acid (GHB), gamma-butyrolactone (GBL), and 1,4-butanediol (1,4-BD) in different rat lines. Annals of the New York Academy of Science. 2006 Aug;1074:545-58.
This article is issued from
Wikipedia.
The text is licensed under Creative
Commons - Attribution - Sharealike.
Additional terms may apply for the media files.