Rafoxanide

Rafoxanide
Names
	IUPAC name N-[3-Chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
	Other names Rafoxanid, raphoxanide
Identifiers
CAS Number	22662-39-1 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL287542 ;
ChemSpider	29191 ;
ECHA InfoCard	100.041.029
EC Number	245-148-9;
KEGG	D05693 ;
MeSH	D011888
PubChem CID	31475;
UNII	22F4FLA7DH ;
CompTox Dashboard (EPA)	DTXSID5046227 ;
	InChI InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) Key: NEMNPWINWMHUMR-UHFFFAOYSA-N ; InChI=1/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26) Key: NEMNPWINWMHUMR-UHFFFAOYAP;
	SMILES C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=CC(=CC(=C3O)I)I)Cl)Cl;
Properties
Chemical formula	C19H11Cl2I2NO3
Molar mass	626.01 g/mol
Appearance	Slight yellowish-brown injectable solution and white oral solution
Solubility in water	In oily solutes
Pharmacology
ATCvet code	QP52AG05 (WHO)
Hazards
Main hazards	Has low safety index (6 times as normal dose)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Rafoxanide is a salicylanilide used as an anthelmintic.[1] It is most commonly used in ruminant animals to treat adult liver flukes of the species Fasciola hepatica and Fasciola gigantica.[1]

References

Lanusse, Carlos E.; Alvarez, Luis I.; Virkel, Guillermo L. (2018). "Chapter 40. Anticestodal and antitrematodal drugs. Rafoxanide". In Riviere, Jim E.; Papich, Mark G. (eds.). Veterinary Pharmacology and Therapeutics (10th ed.). John Wiley & Sons. p. 1091. ISBN 9781118855829.

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[Lanusse_2018-1] Lanusse, Carlos E.; Alvarez, Luis I.; Virkel, Guillermo L. (2018). "Chapter 40. Anticestodal and antitrematodal drugs. Rafoxanide". In Riviere, Jim E.; Papich, Mark G. (eds.). Veterinary Pharmacology and Therapeutics (10th ed.). John Wiley & Sons. p. 1091. ISBN 9781118855829.