Prorenin

Prorenin (/prəˈriːnɪn/[1]) is a protein that constitutes a precursor for renin,[2][3] the hormone that activates the renin–angiotensin system, which serves to raise blood pressure. Prorenin is converted into renin by the juxtaglomerular cells, which are specialised smooth muscle cells present mainly in the afferent, but also the efferent, arterioles of the glomerular capillary bed.

Blood concentration levels of prorenin are between 5 and 10 times higher than those of renin.[3] There is evidence to suggest that, in diabetes mellitus, prorenin levels are even higher.[3][2][4]

Prorenin was discovered by Eugenie Lumbers[5] in 1971.[6]

References
  1. "Renin | Definition of Renin by Lexico". Lexico Dictionaries | English.
  2. "Prorenin - an overview | ScienceDirect Topics". www.sciencedirect.com.
  3. Jan Danser, A.H. (May 1, 2006). "Prorenin". Hypertension. 47 (5): 824–826. doi:10.1161/01.HYP.0000215952.91959.4a. PMID 16585418.
  4. Jan Danser, A. H.; Batenburg, Wendy W.; van Esch, Joep H. M. (May 1, 2007). "Prorenin and the (pro)renin receptor—an update". Nephrology Dialysis Transplantation. 22 (5): 1288–1292. doi:10.1093/ndt/gfl846. PMID 17259648 – via academic.oup.com.
  5. Morrison, Janna L.; Lumbers, Eugenie; Bennet, Laura; Black, Jane (November 9, 2013). "Introduction: Celebrating Emeritus Scientia Professor Eugenie R Lumbers AM and Professor Caroline McMillen". Clinical and Experimental Pharmacology and Physiology. 40 (11): 740–742. doi:10.1111/1440-1681.12180.
  6. Lumbers, E. R. (June 30, 1971). "Activation of renin in human amniotic fluid by low pH". Enzymologia. 40 (6): 329–336. PMID 4105386.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.