Placental villous immaturity

Placental villous immaturity is chorionic villous development that is inappropriate for the gestational age.

Placental villous immaturity
Other namesVillous immaturity, villous dysmaturity
Micrograph of villous immaturity. H&E stain.
SpecialtyGynecology, pathology

It is associated with diabetes mellitus[1] and fetal death near term, i.e. intrauterine demise close to the normal gestational period.[2]

Pathology

Placental villous immaturity, as the name implies, is characterized by chorionic villi that are inappropriately developed for the gestational age. The development and maturation of chorionic villi is essential for normal fetal development.

Immature chorionic villi are larger and have more central blood vessels; thus, the diffusion distance for gas and nutrient exchange is larger and, therefore, placental function is impaired.

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See also

References
  1. Arizawa, M.; Nakayama, M.; Kidoguchi, K. (Jun 1991). "[Correlation of placental villous immaturity and dysmaturity with clinical control of maternal diabetes]". Nihon Sanka Fujinka Gakkai Zasshi. 43 (6): 595–602. PMID 1856519.
  2. Stallmach, T.; Hebisch, G. (Jul 2004). "Placental pathology: its impact on explaining prenatal and perinatal death" (PDF). Virchows Arch. 445 (1): 9–16. doi:10.1007/s00428-004-1032-2. PMID 15138817.
Classification
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