PinT small RNA

PinT sRNA
	Predicted secondary structure and sequence conservation of PinT small RNA
Identifiers
Rfam	RF01404
Other data
Domain(s)	Bacteria
SO	0001263
PDB structures	PDBe

In bacteria, PinT small RNA is a small regulatory RNA (sRNA) that is activated during stress and virulence conditions. sRNAs base-pair with target mRNAs and modulate their stability or translation. The expression of PhoP-activated sRNA called PinT is highly induced during Salmonella enterica infection. PinT temporally controls Salmonella virulence genes. On bacterial internalization it controls the expression of invasion associated effectors (SPI-1) through the direct base-pairing with the mRNA. Later in infection it represses the virulence genes (SPI-2) allowing the switch from an invasive state to the state of intracellular replication.[1]

References

Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (January 2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.

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[1] Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J (January 2016). "Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions". Nature. 529 (7587): 496–501. doi:10.1038/nature16547. PMID 26789254.