Phenprocoumon

Phenprocoumon
Clinical data
Trade names	Marcoumar, Marcumar, Falithrom
AHFS/Drugs.com	International Drug Names
MedlinePlus	a699003
ATC code	B01AA04 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	99%
Metabolism	hepatic to inactive metabolites
Elimination half-life	5 to 6 days
Identifiers
	IUPAC name (RS)-4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one;
CAS Number	435-97-2 ;
PubChem CID	9908;
IUPHAR/BPS	6839;
DrugBank	DB00946 ;
ChemSpider	10441592 ;
UNII	Q08SIO485D;
KEGG	D05457 ;
ChEBI	CHEBI:50438 ;
ChEMBL	ChEMBL1465 ;
CompTox Dashboard (EPA)	DTXSID5023459 ;
ECHA InfoCard	100.006.464
Chemical and physical data
Formula	C18H16O3
Molar mass	280.318 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC=1c3ccccc3OC(=O)C=1C(CC)c2ccccc2;
	InChI InChI=1S/C18H16O3/c1-2-13(12-8-4-3-5-9-12)16-17(19)14-10-6-7-11-15(14)21-18(16)20/h3-11,13,19H,2H2,1H3 ; Key:DQDAYGNAKTZFIW-UHFFFAOYSA-N ;
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Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1]

References

Phenprocoumon at PharmGKB

External links

DDB 29943

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[1] Phenprocoumon at PharmGKB