Oxyphil cell (parathyroid)

In the parathyroid gland, the parathyroid oxyphil cell is larger and lighter staining than the parathyroid chief cell.[1]

Oxyphil cell
High magnification micrograph of parathyroid. H&E stain. The cells with orange/pink staining cytoplasm are oxyphil cells
Details
LocationParathyroid gland
Identifiers
THH3.08.02.5.00005
Anatomical terms of microanatomy

These cells can be found in clusters in the center of the section and at the periphery.[2][3][4][5] Oxyphil cells appear at the onset of puberty, but have no known function. With nuclear medicine scans, they selectively take up the Technetium-sestamibi complex radiotracer to allow delineation of glandular anatomy.[6] Oxyphil cells have been shown to express parathyroid-relevant genes found in the chief cells and have the potential to produce additional autocrine/paracrine factors, such as parathyroid hormone-related protein (PTHrP) and calcitriol.[7] More work needs to be done to fully understand the functions of these cells and their secretions.

See also

References
  1. Histology image:15002loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
  2. Gartner, p. 208, Fig. 3
  3. Ross, p. 628, Fig. 1
  4. DiFiore, pp. 270 - 271
  5. Wheater, pp. 312 - 313
  6. "Minimally Invasive Radio-guided Surgery for Primary Hyperparathyroidism," Annals of Surgical Oncology 12/07 14(12) pp 3401-3402
  7. Ritter, Haughey, Miller, Brown (2012). "Differential gene expression by oxyphil and chief cells of human parathyroid glands". J Clin Endocrinol Metab. 97 (8): E1499–505. doi:10.1210/jc.2011-3366. PMC 3591682. PMID 22585091.CS1 maint: multiple names: authors list (link)


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