Nifuroxazide

Nifuroxazide (INN) is an oral nitrofuran antibiotic, patented since 1966[1] and used to treat colitis and diarrhoea in humans and non-humans.[2] It is sold under the brand names Ambatrol, Antinal, Bacifurane, Diafuryl (Turkey), Pérabacticel (France), Antinal, Diax (Egypt), Nifrozid, Ercefuryl (Romania, Czech Republic, Russia), Erfuzide (Thailand), Endiex (Slovakia), Enterofuryl (Russia), Pentofuryl (Germany), Topron, Enterovid (Latin America), Eskapar (Mexico), Enterocolin,TERRACOLIN 100Mg./200Mg.(Bolivia), Apazid (Morocco), Nifural (Indonesia) and Septidiaryl. It is sold in capsule form and also as a suspension. A 2016 clinical trial showed Nifuroxazide to be more effective compared to probiotics in treating acute diarrhea in adults.[3]

Nifuroxazide
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.012.293
Chemical and physical data
FormulaC12H9N3O5
Molar mass275.2 g/mol g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

History

Maurice Claude Ernest Carron patented the drug in the United States in 1966.[1] Subsequent patents issued to Germano Cagliero of Marxer S.p.A describe the use of nifuroxazide as an antibiotic used to treat livestock.[2]

Effectiveness in humans

In 1997, in an Ivory Coast promotional leaflet, GlaxoSmithKline claimed that nifuroxazide (under the brand name "Ambatrol") is an anti-dehydration treatment, "neutralise[s] microbacterials" in diarrhoea, and has "a spectrum which covers most enteropathogenic microbacterials, Shigella, Escherichia coli, Salmonella, Staphylococci, Klebsiella, Yersinia".[4] The international non-profit organization Healthy Skepticism, at the time using their former name, Medical Lobby for Appropriate Marketing (MaLAM), disagreed, stating "We have not found any scientific evidence to support these claims."[4] A 2016 clinical trial showed Nifuroxazide to treat diarrhea in an average of 2 days compared to 5 days with probiotics.[3]

Notes

  1. USPTO No. 3290213 |http://www.google.com/patents?id=f2dwAAAAEBAJ
  2. USPTO No 4093746 |http://www.google.com/patents?vid=USPAT4093746
  3. Begovic, B.; Ahmedtagic, S.; Calkic, L.; Vehabović, M.; Kovacevic, S. B.; Catic, T.; Mehic, M. (2016). "Open Clinical Trial on Using Nifuroxazide Compared to Probiotics in Treating Acute Diarrhoeas in Adults". Materia Socio-Medica. 28 (6): 454–458. doi:10.5455/msm.2016.28.454-458. PMC 5239654. PMID 28144199.
  4. "SmithKline Beecham Ambatrol (nifuroxazide)". Healthy Skepticism. June 1997. Archived from the original on 2010-12-21. Retrieved 2010-12-21.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.