Neuromuscular disease

Symptoms of neuromuscular disease may include the following:[2][5]

Neuromuscular disease can be caused by autoimmune disorders,[1] genetic/hereditary disorders[2] and some forms of the collagen disorder Ehlers–Danlos Syndrome,[6] exposure to environmental chemicals and poisoning which includes heavy metal poisoning.[3] The failure of the electrical insulation surrounding nerves, the myelin, is seen in certain deficiency diseases, such as the failure of the body's system for absorbing vitamin B-12[3]

Diseases of the motor end plate include myasthenia gravis, a form of muscle weakness due to antibodies against acetylcholine receptor,[7] and its related condition Lambert-Eaton myasthenic syndrome (LEMS).[8] Tetanus and botulism are bacterial infections in which bacterial toxins cause increased or decreased muscle tone, respectively.[9] Muscular dystrophies, including Duchenne's and Becker's, are a large group of diseases, many of them hereditary or resulting from genetic mutations, where the muscle integrity is disrupted, they lead to progressive loss of strength and decreased life span.[10]

Further causes of neuromuscular diseases are :

Polymyositis

Inflammatory muscle disorders

• Polymyalgia rheumatica (or "muscle rheumatism") is an inflammatory condition that mainly occurs in the elderly; it is associated with giant-cell arteritis(It often responds to prednisolone).[11]
• Polymyositis is an autoimmune condition in which the muscle is affected.[12]
• Rhabdomyolysis is the breakdown of muscular tissue due to any cause.[13]

Tumors

• Smooth muscle: leiomyoma (benign)[14]
• Striated muscle: rhabdomyoma (benign)[15]

Nerve conduction velocity (study)

Diagnostic procedures that may reveal muscular disorders include direct clinical observations. This usually starts with the observation of bulk, possible atrophy or loss of muscle tone. Neuromuscular disease can also be diagnosed by testing the levels of various chemicals and antigens in the blood, and using electrodiagnostic medicine tests[16] including electromyography[17] (measuring electrical activity in muscles) and nerve conduction studies.[18]

In neuromuscular disease evaluation, it is important to perform musculoskeletal and neurologic examinations. Genetic testing is an important part of diagnosing inherited neuromuscular conditions.[16]

Prognosis and management vary by disease.

• List of neuromuscular disorders
• Motor neuron diseases
• ICD-10 Chapter XIII: Diseases of the musculoskeletal system and connective tissue
• Neuromuscular medicine

• Wokke, John H. J.; Doorn, Pieter A. van; Hoogendijk, Jessica E.; Visser, Marianne de (2013-03-07). Neuromuscular Disease: A Case-Based Approach. Cambridge University Press. ISBN 9781107328044.
• Ambrosino, N; Carpene, N; Gherardi, M (2009). "Chronic respiratory care for neuromuscular diseases in adults". European Respiratory Journal. 34 (2): 444–451. doi:10.1183/09031936.00182208. PMID 19648521.