National Institute for Medical Research

Henry Hallett Dale

The Medical Research Council, founded in 1913, was immediately charged with establishing a central research institute in London. Later that year, premises at Hampstead were acquired and the National Institute for Medical Research was founded.

However, the outbreak of World War I soon afterwards postponed occupation of the building, although senior staff were appointed and began work. By 1920 the Institute at Mount Vernon Hospital was fully operational and remained so for 30 years until the move to its current location at Mill Hill. The original Institute, under the directorship of Sir Henry Dale, had three divisions:

• Bacteriology
• Biochemistry and Pharmacology
• Applied Physiology

Dale oversaw a period of considerable success at NIMR, including the discovery of the human influenza virus in 1933 and the discovery of the neurotransmitter acetylcholine, for which Dale himself received the 1936 Nobel Prize in Physiology or Medicine.

Helio Pereira, the then-Director of the World Influenza Centre at NIMR Mill Hill, oversees flu virus research

In the 1930s, the decision was made to move the Institute to new premises. An imposing copper-roofed building at Mill Hill was designed by Maxwell Ayrton, the architect of the original Wembley Stadium, and construction began in 1937. Occupation was delayed when war broke out in 1939 and the building was given to the Women's Royal Naval Service. The building was returned to the MRC in autumn 1949 but Dale had retired in 1942 and so was never director on the new site, that job falling to his successor Sir Charles Harington.

NIMR lab technicians in 1950

The official opening ceremony took place on 5 May 1950, with King George VI and Queen Elizabeth present. Harington expanded the research programme into ten divisions during his 20-year tenure and guided researchers at the Institute to, amongst other achievements, the development of gas chromatography and the discovery of interferon. From 1950-55 Albert Neuberger was Head of Biochemistry at the Institute.

In 1962, Nobel Prize winner Sir Peter Medawar became director and, consistent with his research interests, established NIMR as a major centre for immunological research. Following an illness, Medawar retired as director in 1971 to be replaced by Sir Arnold Burgen. Burgan had an interest in nuclear magnetic resonance techniques and formed the MRC Biomedical NMR Centre at the Institute in 1980. Sir Dai Rees became director in 1982 to be replaced by Sir John Skehel in 1987. Since then NIMR has continued to excel scientifically, reporting perhaps most famously the discovery of the sex determining gene SRY, in 1991.

Demolition began in April 2018

In 2003, as part of their Forward Investment Strategy, the MRC announced plans to consider moving NIMR from its current location to a university/medical school site, to enhance its ability "to translate its biomedical research into practical health outcomes." [1][2] University College London was selected as a preferred partner institution, and a nearby site in central London was acquired.[3]

Some staff at the NIMR, including Robin Lovell-Badge and Skehel, expressed opposition to a move. In response to accusations of "coercion" during the review process, a House of Commons select committee investigation criticised both the MRC for losing the confidence of NIMR workers, and unnamed NIMR staff for "undermining [Colin] Blakemore's position as MRC chief executive." [4][5]

In September 2006, Skehel retired as NIMR director [6] and Sir Keith Peters became acting director [7] until the future structure of the new institute could be finalised. In July of that year the MRC announced that Scott Fraser of the California Institute of Technology had been invited to take over the directorship. [8] According to Blakemore, negotiations were ongoing as of December 2006.[2] However, finally, in October 2008, Jim Smith of the Gurdon Institute, University of Cambridge (who worked at the NIMR from 1984 to 2000), accepted the directorship, with effect from January 2009.

On 1 April 2015, the NIMR became part of the new Francis Crick Institute[9] and ceased to exist as a separate MRC institute. The site at Mill Hill was fully vacated and closed for redevelopment during 2017.

In 2018 they started to demolish the building to make way for new homes.[10]

A yearly collection of essays is produced by guest authors and staff at the Institute, under the title Mill Hill Essays.[11] They are written to be accessible and informative to the lay reader.