National Human Genome Research Institute

NHGRI is organized into seven divisions and the Office of the Director.[1] Four of these divisions support extramural research (the grant-giving side), one coordinates the intramural (on-campus) research arm of the institute, one deals with administration, management, and budget, and one serves as the public-facing side of the institute housing the communications, policy, and education teams.

• October 1, 1988 – The Office for Human Genome Research is created within the Office of the Director, National Institutes of Health (NIH). Also, NIH and the Department of Energy (DOE) sign a memorandum of understanding to "coordinate research and technical activities related to the human genome."
• April 11, 1996 – Human DNA sequencing begins with pilot studies at six universities in the United States.
• March 1999 – Large-scale sequencing of the human genome begins.
• April 2003 – The National Human Genome Research Institute (NHGRI) celebrates the completion of the human genome sequence, the 50th anniversary of the description of the DNA double helix and the publication of the vision document for the future of genomics research.
• May 4, 2007 – The National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), have teamed with Group Health Cooperative in Seattle and Henry Ford Health System in Detroit to launch the Multiplex Initiative,[2] a study to investigate the interest level of healthy, young adults in receiving genetic testing for eight common conditions.
• May 28, 2008 – Francis S. Collins steps down as Director of the Institute after serving for fifteen of the nineteen years of its operation.[3] Alan Edward Guttmacher has been appointed acting director while a new permanent director is sought.[4]
• November 17, 2009 – NIH Appoints Eric D. Green, M.D., Ph.D. to be Director of The National Human Genome Research Institute. It is the first time an institute director has risen to lead the entire NIH and subsequently picked his own successor.

In 1990 as part of the Human Genome Project, the NHGRI dedicated 5% of its annual budget to explore the ethical, legal, and social implications of genomic research. This program's current priorities focus on the ethical applications of genomics to as it applies to communities, families, and individuals in areas such as healthcare, research, defense, intellectual property, regulation, policy, and larger social issues.[5] In 2004 the ELSI program established several Centers for Excellence in ELSI research (CEER). It was funded with substantial contributions from the U.S. Department of Energy and the National Institute of Child Health and Human Development. CEER centers have a common focus on the ethical, social, and legal implications resulting from the advances in genomic research.[6]

The initial centers were[7]

• Case Western Reserve University's Center for Genetic Research Ethics and Law; Eric Juengst, Ph.D., $5.3 million
• The Duke Center for the Study of Public Genomics; Robert Cook-Deegan, M.D., $4.8 million
• Stanford University School of Medicine's Center for Integration of Research on Genetics and Ethics; Mildred Cho, Ph.D., $3.8 million
• University of Washington's Center for Genomics and Healthcare Equality; Wylie Burke, M.D., Ph.D., $4.7 million

This center is focused on equitable distribution and use of translational genome research in underserved and marginalized communities. CGHE has several cores working to address different lenses of health disparities, genomic research, and outreach education. These cores include the Partnership core, the Genome Sciences core, the Healthcare Decision-making core and the Indigenous Genomics Alliance.[8]

The NHGRI is publicly funded. In support of moving to a translational model, the NHGRI published their funding mechanisms for ELSI research.[9]

• Julie Segre, Chief and Senior Investigator of the Translational and Functional Genomics Branch
• Talking Glossary of Genetic Terms

• NHGRI Homepage (Genome.gov)
• CGHE CEER (Wayback Machine copy)
• NHGRI CEER