N,N-Dimethylethylamine (DMEA), sometimes referred to as dimethylethylamine, is an organic compound with formula C4H11N. It is an industrial chemical that is mainly used in foundries as a catalyst for sand core production. Dimethylethylamine is a malodorous, volatile liquid at room temperature that is excreted at greater concentrations with larger dietary intake of trimethylamine. It has recently been identified as an agonist of human trace amine-associated receptor 5.
Dimethyl ethyl amine
|Preferred IUPAC name
N,N-Dimethyl ethyl amine
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||73.139 g·mol−1|
|Appearance||Volatile liquid at room temp.|
|Melting point||−140 °C (−220 °F; 133 K)|
|Boiling point||36.5 °C (97.7 °F; 309.6 K)|
|Vapor pressure||495.4±0.1 mmHg|
|Acidity (pKa)||10.16 (for the conjugate acid) (H2O)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
- "N,N-Dimethylethylamine". Toxnet. Hazardous Substance Data Bank. Retrieved 4 May 2014.
The aim was to study the effect of trimethylamine (TMA) on the metabolism of the industrial catalyst N,N-dimethylethylamine to ascertain whether biological monitoring of industrial exposure to N,N-dimethylethylamine is compromised and excretion of the malodorous N,N-dimethylethylamine in sweat and urine is increased by dietary intake of TMA....Although the increased urinary and hidrotic excretion of N,N-dimethylethylamine may contribute to body odor problems, they were primarily due to TMA excretion, which is much the greater.
- "Dimethylethylamine". BASF The Chemical Company. Retrieved 4 May 2014.
- Wallrabenstein I, Kuklan J, Weber L, Zborala S, Werner M, Altmüller J, Becker C, Schmidt A, Hatt H, Hummel T, Gisselmann G (2013). "Human trace amine-associated receptor TAAR5 can be activated by trimethylamine". PLoS ONE. 8 (2): e54950. doi:10.1371/journal.pone.0054950. PMC 3564852. PMID 23393561.