Morniflumate

Morniflumate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M01AX22 (WHO) ;
Identifiers
	IUPAC name 2-morpholin-4-ylethyl 2-{[3-(trifluoromethyl)phenyl]amino}nicotinate;
CAS Number	65847-85-0 ;
PubChem CID	72106;
ChemSpider	65089 ;
UNII	R133MWH7X1;
KEGG	D05078 ;
CompTox Dashboard (EPA)	DTXSID6057798 ;
ECHA InfoCard	100.207.566
Chemical and physical data
Formula	C19H20F3N3O3
Molar mass	395.37561 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1cc(ccc1)Nc2ncccc2C(=O)OCCN3CCOCC3;
	InChI InChI=1S/C19H20F3N3O3/c20-19(21,22)14-3-1-4-15(13-14)24-17-16(5-2-6-23-17)18(26)28-12-9-25-7-10-27-11-8-25/h1-6,13H,7-12H2,(H,23,24) ; Key:LDXSPUSKBDTEKA-UHFFFAOYSA-N ;
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Morniflumate is a nonsteroidal anti-inflammatory drug (NSAID).[1][2][3]

References

Melica, A.; Donateo, L.; Gerardi, R.; Parenti, M. (1991). "A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis". Rivista europea per le scienze mediche e farmacologiche = European Review for Medical and Pharmacological Sciences = Revue europeenne pour les sciences medicales et pharmacologiques. 13 (1–2): 51–60. PMID 1796197.
Civelli, M.; Vigano, T.; Acerbi, D.; Caruso, P.; Giossi, M.; Bongrani, S.; Folco, G. C. (1991). "Modulation of arachidonic acid metabolism by orally administered morniflumate in man". Agents and Actions. 33 (3–4): 233–239. doi:10.1007/bf01986568. PMID 1659152.
Schiantarelli, P.; Cadel, S.; Acerbi, D. (1984). "A gastroprotective anti-inflammatory agent: Theβ-morpholinoethyl ester of niflumic acid (morniflumate)". Agents and Actions. 14 (2): 247–256. doi:10.1007/BF01966649. PMID 6608862.

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[1] Melica, A.; Donateo, L.; Gerardi, R.; Parenti, M. (1991). "A new anti-inflammatory-analgesic-antipyretic, morniflumate, in the treatment of chronic recurring bronchitis". Rivista europea per le scienze mediche e farmacologiche = European Review for Medical and Pharmacological Sciences = Revue europeenne pour les sciences medicales et pharmacologiques. 13 (1–2): 51–60. PMID 1796197.

[2] Civelli, M.; Vigano, T.; Acerbi, D.; Caruso, P.; Giossi, M.; Bongrani, S.; Folco, G. C. (1991). "Modulation of arachidonic acid metabolism by orally administered morniflumate in man". Agents and Actions. 33 (3–4): 233–239. doi:10.1007/bf01986568. PMID 1659152.

[3] Schiantarelli, P.; Cadel, S.; Acerbi, D. (1984). "A gastroprotective anti-inflammatory agent: Theβ-morpholinoethyl ester of niflumic acid (morniflumate)". Agents and Actions. 14 (2): 247–256. doi:10.1007/BF01966649. PMID 6608862.

Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.