Meesmann corneal dystrophy

Meesmann corneal dystrophy is a type of corneal dystrophy and a keratin disease.

Meesmann juvenile epithelial corneal dystrophy
Other namesStocker-Holt dystrophy
Multiple opaque spots in the corneal epithelium
SpecialtyOphthalmology

It is named for German ophthalmologist Alois Meesmann (1888-1969).[1][2]

It is sometimes called "Meesmann-Wilke syndrome", after the joint contribution of Meesmann and Wilke.[1][3]

Presentation

This slowly progressive disorder is characterized by small cysts in the epithelium of the cornea. Patients with Meesmann corneal dystrophy are intolerant of contact lenses, as these devices directly traumatize the corneal epithelium.

Genetics

It has been associated with genes KRT3 and KRT12 located on chromosome 12 and 17 respectively.[4]

Diagnosis

See also

References
  1. synd/3139 at Who Named It?
  2. A. Meesmann. Klinische und anatomische Untersuchungen über eine bisher unbekannte, dominant vererbte Dystrophia epithelialis corneae. Bericht der Deutschen ophthalmologischen Gesellschaft, Heidelberg, 1938, 52: 154-158.
  3. A. Meesmann, F. Wilke. Klinische und anatomische Untersuchungen über eine bisher unbekannte, dominant vererbte Epithel Dystrophie der Horn haut. Klinische Monatsblätter für Augenheilkunde, Stuttgart, 1939, 103: 361-391.
  4. Online Mendelian Inheritance in Man (OMIM) 122100
Classification
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