Manchester score

Manchester score is an indicator of prognosis in small cell lung cancer.[1][2] It is calculated from a number of physical and biochemical markers.

A patient with small cell lung cancer scores one point for each of the following: -

  • Serum lactate dehydrogenase exceeds the upper limit of the reference range.
  • Serum sodium concentration less than 132 mmol/l.
  • Serum alkaline phosphatase over one-and-a-half times the upper limit of the reference range.
  • Serum bicarbonate less than 24.
  • Karnofsky performance status less than 60.
  • Extensive stage disease.


Prognosis of small cell lung cancer according to Manchester score[3]
Manchester scorePrognostic groupTwo year survival (%)
0-1 Good 16.2
2-3 Medium 2.5
4 or more Poor 0


  1. Cerny, T; Blair V; Anderson H; et al. (1987). "Pretreatment prognostic factors and scoring system in 407 small-cell lung cancer patients". International Journal of Cancer. 39 (2): 146–149. doi:10.1002/ijc.2910390204. PMID 3026969.
  2. Kawahara, Masaaki; Masahiro Fukuoka; Nagahiro Saijo; et al. (1996). "Prognostic factors and prognostic staging system for small cell lung cancer". Japanese Journal of Clinical Oncology. Oxford University Press. 27 (3): 158–165. doi:10.1093/jjco/27.3.158. ISSN 0368-2811. PMID 9255270.
  3. Maestu, I; Pastor M; Gómez-Codina J; et al. (Jun 1997). "Pretreatment prognostic factors for survival in small-cell lung cancer: a new prognostic index and validation of three known prognostic indices on 341 patients". Annals of Oncology. 8 (6): 547–553. doi:10.1023/A:1008212826956. PMID 9261523.
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