Lowenberg's sign

Lowenberg's sign is a clinical sign found in patients with deep vein thrombosis of the lower leg. The sign is positive when pain is elicited rapidly when a blood pressure cuff is placed around the calf and inflated to 80mmHg. Like other signs of deep vein thrombosis, such as Homans sign and Bancroft's sign, this sign is neither sensitive nor specific for the presence of thrombosis.[1][2]

Lowenberg's sign
Differential diagnosisdeep vein thrombosis

The sign is named after Dr. Robert I. Lowenberg (19172000), M.D. who described it in 1954.[3]


  1. "Chapter 18: History, Physical Examination, and Diagnostic Approach". Manual of Vascular Diseases. Sanjay Rajagopalan, Debabrata Mukherjee, Emile R. Mohler. Lippincott Williams & Wilkins. 2004. p. 258. ISBN 978-0-7817-4499-7.CS1 maint: others (link)
  2. Assessment of the Elderly Patient: The Peripheral Vascular Examination: Venous Examinations at Medscape.
  3. Lowenberg, R. I. (1954). "Early Diagnosis of Phlebo Thrombosis with Aid of a New Clinical Test". JAMA: The Journal of the American Medical Association. 155 (18): 1566–70. doi:10.1001/jama.1954.03690360018005. PMID 13183782.
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