Lokivetmab

Lokivetmab, trade name Cytopoint, is a monoclonal antibody used to treat atopic dermatitis in dogs.[1] It acts against interleukin 31 (IL-31),[2] which is a cytokine involved in causing itchiness (pruritus).[2] Lokivetmab is administered by subcutaneous injection; each dose is effective for four to eight weeks.[3]

Lokivetmab
Monoclonal antibody
TypeWhole antibody
Targetinterleukin 31 (IL-31)
Clinical data
Trade namesCytopoint
Routes of
administration		subcutaneous
ATCvet code
Legal status
Legal status
  • veterinary use
Identifiers
UNII

The United States Department of Agriculture (USDA) approved lokivetmab (manufactured by Zoetis and sold under the trade name Cytopoint) in December 2016,[3] and it was approved by the European Medicines Agency in 2017.[4] Lokivetmab was the first monoclonal antibody to be approved for use in animals in the European Union.[4]

References
  1. "Zoetis earns license for Cytopoint skin therapy". Veterinary Practice News. 4 January 2017. Retrieved 2018-07-06.
  2. Marsella, R; De Benedetto, A (26 July 2017). "Atopic dermatitis in animals and people: an update and comparative review". Veterinary Sciences. 4 (3): 37. doi:10.3390/vetsci4030037. PMC 5644664. PMID 29056696.
  3. McKay, Lindsay (13 July 2017). "Making a difference for dogs with atopic dermatitis: When to use Apoquel and when to use Cytopoint". dvm360.com. Retrieved 2018-07-07.
  4. "First antibody therapy in veterinary medicine launched for dogs in the UK". Veterinary Record. 181 (1): 6–7. 30 June 2017. doi:10.1136/vr.j3147. PMID 28667135.


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