List of target antigens in pemphigus

Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.

Target antigens for the different pemphigus variants
Pemphigus variantAntibody isotypeAntigenMolecular weight (KDa)
Mucosal pemphigus vulgarisIgGDesmoglein 3130
Mucocutaneous pemphigus vulgarisIgGDesmoglein 3
Desmoglein 1
130
160
Pemphigus foliaceusIgGDesmoglein 1160
Paraneoplastic pemphigusIgGDesmoglein 3
Desmoglein 1
BPAG1[nb 1]
Plectin
Desmoplakin I[nb 2]
Desmoplakin II
Envoplakin
Periplakin
Alpha-2-macroglobulin-like-1
130
160
230
500
250
210
210
190
170
Drug-induced pemphigusIgGDesmoglein 3
Desmoglein 1
130
160
Subcorneal pustular dermatosis type of IgA pemphigusIgA1Desmocollin 1110/100
Intraepidermal neutrophilic type of IgA pemphigusIgA1Unknown
Pemphigus erythematosus (Senear–Usher syndrome)[nb 3]IgGDesmoglein 1160
Fogo selvagemIgGDesmoglein 1160
Pemphigus vegetansIgGDesmoglein 3130
Pemphigus vegetans of Hallopeau[nb 4]IgGDesmoglein 3130
Pemphigus vegetans of Neumann[nb 4]IgGDesmoglein 3130
Pemphigus herpetiformisIgGDesmoglein 3
Desmoglein 1
130
160

Footnotes

  1. Notably not BPAG2
  2. Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
  3. Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
  4. Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.

See also

References

    • Bolognia, Jean L.; et al. (2007). Dermatology. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
    • James, William D.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
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