List of side effects of tramadol

The most common side effects of tramadol in order of decreasing incidence are:[1][2][3][4][5][6][7]
Note: Serious adverse effects are in bold.

Very common (>10% frequency)

Dizziness
Nausea
Constipation
Vertigo
Headache
Vomiting
Somnolence (drowsiness)

Common (1–10% frequency)

Agitation
Anxiety
Emotional lability
Euphoria
Nervousness
Spasticity
Dyspepsia (indigestion)
Asthenia (weakness)
Pruritus (itchiness)
Dry mouth
Diarrhea
Fatigue
Sweating
Malaise
Vasodilation (dilation (widening) of blood vessels)
Confusion
Coordination disturbance
Miosis
Sleep disorder
Rash
Hypertonia
Abdominal pain
Weight loss
Visual disturbance
Flatulence
Menopausal symptoms
Urinary frequency
Urinary retention (being unable to urinate)

Uncommon (0.1-1% incidence)

Cardiovascular regulation anomalies (palpitation, tachycardia, postural hypotension or cardiovascular collapse)
Retching
Gastrointestinal irritation (a feeling of pressure in the stomach, bloating)
Urticaria (hives)
Trembling
Flushing

Rare (0.01–0.1% incidence)

Bradycardia
Hypertension (high blood pressure)
Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema)
Anaphylaxis
Changes in appetite
Paraesthesia (pins and needles)
Hallucinations
Tremor
Respiratory depression
Epileptiform convulsions
Involuntary muscle contractions
Abnormal coordination
Syncope (fainting)
Blurred vision
Dyspnoea (shortness of breath)
Tinnitus (ringing in the ears)
Migraine
Stevens-Johnson syndrome/Toxic epidermal necrolysis (potentially fatal skin reactions)
Motorial weakness
Creatinine increase
Elevated liver enzymes
Hepatitis (liver swelling)
Stomatitis (mouth swelling)
Liver failure
Pulmonary oedema (fluid in the lungs)
Gastrointestinal bleeding
Pulmonary embolism
Myocardial ischaemia (lack of blood supply to the heart muscles)
Speech disorders
Haemoglobin decrease
Proteinuria (protein in the urine; usually indicative of kidney damage)

References

"Ultram, Ultram ER (tramadol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 28 November 2013.
"PRODUCT INFORMATION Tramadol SANDOZ 50 mg capsules" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 4 November 2011. Retrieved 6 April 2014.
"Tramadol Hydrochloride 50mg Capsules – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 12 June 2013. Retrieved 28 November 2013.
"Tilodol SR 100 mg Prolonged-Release Tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 6 March 2013. Retrieved 28 November 2013.
"PRODUCT INFORMATION TRAMADOL SANDOZ® SR 100MG, 150MG and 200MG SUSTAINED RELEASE TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 21 November 2013. Retrieved 28 November 2013.
"ULTRAM (TRAMADOL HYDROCHLORIDE) TABLET, COATED [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". DailyMed. LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC. November 2012. Retrieved 28 November 2013.
"ULTRAM ER (TRAMADOL HYDROCHLORIDE) TABLET, EXTENDED RELEASE [REBEL DISTRIBUTORS CORP]". DailyMed. Rebel Distributors Corp. December 2010. Retrieved 28 November 2013.

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[MSR-1] "Ultram, Ultram ER (tramadol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 28 November 2013.

[TGAIR-2] "PRODUCT INFORMATION Tramadol SANDOZ 50 mg capsules" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 4 November 2011. Retrieved 6 April 2014.

[EMCIR-3] "Tramadol Hydrochloride 50mg Capsules – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 12 June 2013. Retrieved 28 November 2013.

[EMCSR-4] "Tilodol SR 100 mg Prolonged-Release Tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 6 March 2013. Retrieved 28 November 2013.

[TGASR-5] "PRODUCT INFORMATION TRAMADOL SANDOZ® SR 100MG, 150MG and 200MG SUSTAINED RELEASE TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 21 November 2013. Retrieved 28 November 2013.

[DMIR-6] "ULTRAM (TRAMADOL HYDROCHLORIDE) TABLET, COATED [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". DailyMed. LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC. November 2012. Retrieved 28 November 2013.

[DMSR-7] "ULTRAM ER (TRAMADOL HYDROCHLORIDE) TABLET, EXTENDED RELEASE [REBEL DISTRIBUTORS CORP]". DailyMed. Rebel Distributors Corp. December 2010. Retrieved 28 November 2013.