Leukoencephalopathy with neuroaxonal spheroids

Leukoencephalopathy with neuroaxonal spheroids is a special kind of leukoencephalopathy. It is a cause of severe and subacute dementia. It is inherited, following an autosomal dominant pattern.

Leukoencephalopathy with neuroaxonal spheroids
This condition is inherited in an autosomal dominant manner
SpecialtyNeurology

It usually presents in childhood but it can also have an adult onset,[1] in which case it can present MRIs that mimic those of progressive multiple sclerosis.[2]

See also

References
  1. Adams SJ, Kirk A, Auer RN (2018). "Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Integrating the literature on hereditary diffuse leukoencephalopathy with spheroids (HDLS) and pigmentary orthochromatic leukodystrophy (POLD)". Journal of Clinical Neuroscience. 48 (1): 42–49. doi:10.1016/j.jocn.2017.10.060. PMID 29122458.
  2. Keegan BM, Giannini C, Parisi JE, Lucchinetti CF, Boeve BF, Josephs KA (March 2008). "Sporadic adult-onset leukoencephalopathy with neuroaxonal spheroids mimicking cerebral MS". Neurology. 70 (13 Pt 2): 1128–33. doi:10.1212/01.wnl.0000304045.99153.8f. PMID 18287567.
Classification
External resources


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