Hexylresorcinol
Hexylresorcinol is an organic compound with local anaesthetic, antiseptic, and anthelmintic properties.[1]
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| ECHA InfoCard | 100.004.780  |
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| Formula | C12H18O2 |
| Molar mass | 194.27 g·mol−1 |
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It is available for use topically on small skin infections, or as an ingredient in throat lozenges. It is marketed as S.T.37 by Numark Laboratories, Inc. (in a 0.1% solution) for oral pain relief and as an antiseptic. Sytheon Ltd., USA markets hexylresorcinol (trade named Synovea HR). Johnson & Johnson uses hexylresorcinol in its Neutrogena, Aveno, and RoC skincare products as an anti-aging cream. Hexylresorcinol has been used commercially by many cosmetic and personal care companies, such as Mary Kay, Clarins, Unilever, Murad, Arbonne, and many small and large companies.
A study published in Chemical Research in Toxicology [2] shows that 4-hexylresorcinol used as a food additive (E-586) exhibits some estrogenic activity, i.e. resembles action of the female sex hormone estrogen.
In one study, 4-hexylresorcinol increased the shelf life of shrimp by reducing melanosis (black spots).[3]
In mice with cancer, 4-hexylresorcinol inhibited NF-κB and extended their survival rate.[4]
References
- O. Gisvold (1966). C. O. Wilson, O. Gisvold and R. F. Doerge (eds.). Textbook of Organic Medicinal and Pharmaceutical Chemistry (5th ed.). Philadelphia: Lippincott. pp. 237–262.CS1 maint: uses editors parameter (link)
- Amadasi, A; Mozzarelli, A; Meda, C; Maggi, A; Cozzini, P (2009). "Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach". Chem. Res. Toxicol. 22 (1): 52–63. doi:10.1021/tx800048m. PMC 2758355. PMID 19063592.
- Montero, P. (2006). "Effectiveness of Onboard Application of 4-Hexylresorcinol in Inhibiting Melanosis in Shrimp (Parapenaeus longirostris)". Journal of Food Science. 69: C643–C647. doi:10.1111/j.1365-2621.2004.tb09913.x.
- Kim, Seong-Gon (2011). "4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells". Oncology Reports. doi:10.3892/or.2011.1436.