Hepatotoxin
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.
It can be a side-effect of medication, or found naturally, as microcystins, or in laboratory environments.
The effects of hepatotoxins depend on the amount, point of entry and distribution speed of the [toxin], and on the health of the person.
Hepatotoxic substances
- α-amanitin, a deadly cellular toxin found in Amanita phalloides mushroom (death cap)
- Aflatoxin
- Ethanol
- Halothane[1]
- Carbon tetrachloride
- Pyrrolizidine alkaloids, found in many plants in the Boraginaceae, Compositae, and Leguminosae families.
- Luteoskyrin
- allyl alcohol, amiodarone, Aroclor 1254, arsenic, carbamazepine, carbon tetrachloride, diethylnitrosamine, dimethylformamide, diquat, etoposide, indomethacin, methapyrilene, methotrexate, monocrotaline, and 3-methylcholanthrene.[2]
References
- Vardanyan, R. S., and Victor J. Hruby. Synthesis of Essential Drugs. 1st ed. Amsterdam: Elsevier, 2006. Print.
- Waring, JF; Jolly, RA; Ciurlionis, R; Lum, PY; Praestgaard, JT; Morfitt, DC; Buratto, B; Roberts, C; et al. (2001). "Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles". Toxicology and Applied Pharmacology. 175 (1): 28–42. doi:10.1006/taap.2001.9243. PMID 11509024.
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