HBG1

HBG1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1I3D, 1I3E
Identifiers
Aliases	HBG1, HBG-T2, HBGA, HBGR, HSGGL1, PRO2979, hemoglobin subunit gamma 1
External IDs	OMIM: 142200 HomoloGene: 133561 GeneCards: HBG1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	5,249,859 bp[1]
Gene ontology
Molecular function	• oxygen binding; • heme binding; • metal ion binding; • oxygen transporter activity; • peroxidase activity; • protein binding; • haptoglobin binding; • organic acid binding;
Cellular component	• hemoglobin complex; • cytosol; • haptoglobin-hemoglobin complex;
Biological process	• blood coagulation; • oxygen transport; • hydrogen peroxide catabolic process; • protein heterooligomerization; • cellular oxidant detoxification;
	Sources:Amigo / QuickGO
Orthologs
	3047
	n/a
	ENSG00000213934
	n/a
	P69891
	n/a
	NM_000559
	n/a
	NP_000550
	n/a
	Wikidata
View/Edit Human

Hemoglobin subunit gamma-1 is a protein that in humans is encoded by the HBG1 gene.[3]

Function

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) in the year following birth. In the non-pathological condition known as hereditary persistence of fetal hemoglobin (HPFH), gamma globin expression is continued into adulthood. Also, in cases of beta-thalassemia and related conditions, gamma chain production may be maintained, possibly as a mechanism to compensate for the mutated beta-globin. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.[4]

References

GRCh38: Ensembl release 89: ENSG00000213934 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
"Entrez Gene: HBG1 hemoglobin, gamma A".

Huisman TH, Kutlar F, Gu LH (1992). "Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations". Hemoglobin. 15 (5): 349–79. doi:10.3109/03630269108998857. PMID 1802881.
Gelinas R, Yagi M, Endlich B, et al. (1985). "Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene". Prog. Clin. Biol. Res. 191: 125–39. PMID 2413469.
Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects". Mol. Cell. Proteomics. 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
Chang JC, Kan YW (1979). "beta 0 thalassemia, a nonsense mutation in man". Proc. Natl. Acad. Sci. U.S.A. 76 (6): 2886–9. doi:10.1073/pnas.76.6.2886. PMC 383714. PMID 88735.
Saglio G, Ricco G, Mazza U, et al. (1979). "Human T gamma globin chain is a variant of A gamma chain (A gamma Sardinia)". Proc. Natl. Acad. Sci. U.S.A. 76 (7): 3420–4. doi:10.1073/pnas.76.7.3420. PMC 383837. PMID 291015.
Poon R, Kan YW, Boyer HW (1979). "Sequence of the 3'-noncoding and adjacent coding regions of human gamma-globin mRNA". Nucleic Acids Res. 5 (12): 4625–30. PMC 342777. PMID 318163.
Grifoni V, Kamuzora H, Lehmann H, Charlesworth D (1975). "A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2". Acta Haematol. 53 (6): 347–55. doi:10.1159/000208204. PMID 808940.
Proudfoot NJ, Brownlee GG (1976). "3' non-coding region sequences in eukaryotic messenger RNA". Nature. 263 (5574): 211–4. doi:10.1038/263211a0. PMID 822353.
Marotta CA, Forget BG, Cohne-Solal M, et al. (1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019–31. PMID 873928.
Frier JA, Perutz MF (1977). "Structure of human foetal deoxyhaemoglobin". J. Mol. Biol. 112 (1): 97–112. doi:10.1016/S0022-2836(77)80158-7. PMID 881729.
Ahern E, Holder W, Ahern V, et al. (1975). "Haemoglobin F Victoria Jubilee (alpha 2 A gamma 2 80 Asp-Try)". Biochim. Biophys. Acta. 393 (1): 188–94. doi:10.1016/0005-2795(75)90230-5. PMID 1138921.
Waye JS, Cai SP, Eng B, et al. (1993). "Clinical course and molecular characterization of a compound heterozygote for sickle hemoglobin and hemoglobin Kenya". Am. J. Hematol. 41 (4): 289–91. doi:10.1002/ajh.2830410413. PMID 1283810.
Bailey WJ, Hayasaka K, Skinner CG, et al. (1994). "Reexamination of the African hominoid trichotomy with additional sequences from the primate beta-globin gene cluster". Mol. Phylogenet. Evol. 1 (2): 97–135. doi:10.1016/1055-7903(92)90024-B. PMID 1342932.
Gottardi E, Losekoot M, Fodde R, et al. (1992). "Rapid identification by denaturing gradient gel electrophoresis of mutations in the gamma-globin gene promoters in non-deletion type HPFH". Br. J. Haematol. 80 (4): 533–8. doi:10.1111/j.1365-2141.1992.tb04569.x. PMID 1374633.
Berry M, Grosveld F, Dillon N (1992). "A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin". Nature. 358 (6386): 499–502. doi:10.1038/358499a0. PMID 1379347.
Loudianos G, Moi P, Lavinha J, et al. (1993). "Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia". Hemoglobin. 16 (6): 503–9. doi:10.3109/03630269208993118. PMID 1487421.
Fucharoen S, Shimizu K, Fukumaki Y (1990). "A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression". Nucleic Acids Res. 18 (17): 5245–53. doi:10.1093/nar/18.17.5245. PMC 332148. PMID 1698280.
Plaseska D, Kutlar F, Wilson JB, et al. (1991). "Hb F-Jiangsu, the first gamma chain variant with a valine----methionine substitution: alpha 2A gamma 2 134(H12)Val----Met". Hemoglobin. 14 (2): 177–83. doi:10.3109/03630269009046959. PMID 1703137.

External links

Overview of all the structural information available in the PDB for UniProt: P69891 (Hemoglobin subunit gamma-1) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213934 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2649166-3] Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.

[4] "Entrez Gene: HBG1 hemoglobin, gamma A".

HBG1

Function

References

Further reading

External links