Glucuronide

A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond.[1] The glucuronides belong to the glycosides.

Morphine-6-glucuronide, a major metabolite of morphine

Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source. Glucuronic acid is attached via a glycosidic bond to the substance, and the resulting glucuronide, which has a much higher water solubility than the original substance, is eventually excreted by the kidneys.[2]

Enzymes that cleave the glycosidic bond of a glucuronide are called glucuronidases.

Examples

Miquelianin (Quercetin 3-O-glucuronide)
Morphine-6-glucuronide
Scutellarein-7-glucuronide

References

The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company
Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017). "Glucuronidation: driving factors and their impact on glucuronide disposition". Drug Metabolism Reviews. 49 (2): 105–138. doi:10.1080/03602532.2017.1293682. PMID 28266877.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] The American Heritage Medical Dictionary, 2007, Houghton Mifflin Company

[2] Yang G, Ge S, Singh R, Basu S, Shatzer K, Zen M, et al. (May 2017). "Glucuronidation: driving factors and their impact on glucuronide disposition". Drug Metabolism Reviews. 49 (2): 105–138. doi:10.1080/03602532.2017.1293682. PMID 28266877.