Glial tumor

Glial tumor is a general term for numerous tumors of the central nervous system (CNS), including astrocytomas, ependymal tumors, Oligodendroglioma , and primitive neuroectodermal tumors.The world Health Organization (WHO) classifies tumors into different categories according to severity and recurrence.[1]The first tumor classified as grade I is called pilocytic astrocytoma and it is most commonly observed in children rather than adults.[2] The next tumor is very common in the CNS called diffuse astrocytoma and it is considered a grade II, they are benign, or noncancerous, but can become malignant, meaning cancerous, as the tumor progresses. [3][2] Grades III and grade IV are considered malignant astrocytomas. Anaplastic astrocytomas are considered by the WHO to be a grade III astrocytoma and Glioblastoma multiforme is a grade IV both are referred to high-grade astrocytomas.[2]

Another glial tumor type of the CNS are ependymal tumors. These are tumors which have cells which resemble the ependymal cells of the ventricles within the brain and the spinal cord[1]. These too are classified into different categories according to their severity of aggression. Least aggressive ependymal tumors include Subependymomas and Myxopapillary ependymoma which are classified as grade I. The most severe are classified as grade III and are called anaplastic ependymomas and these usually occur at the base of the spine[2].

Oligodendroglioma is another type of glial tumor which, are rate. They normally appear in the white matter of the cerebral hemispheres in the frontal lobes. Although, the causes are not known, there is other studies which, suggest the deletion of 1p/19q is imperative for chemotherapy treatment.[3]. Oligodendroglioma are very different histologically, from brain tissue due to their sharp borders and their distinctive "fried egg" characteristic.[6]


  1. "Ependymal cell | anatomy". Encyclopedia Britannica. Retrieved 2019-04-30.
  2. "Ependymal tumours of the brain and spinal cord: survival rates in England". www.ncin.org.uk. Retrieved 2019-04-30.
  3. "Van den Bent, M. J., Reni, M., Gatta, G., & Vecht, C. (2008). Oligodendroglioma. Critical reviews in oncology/hematology, 66(3), 262-272"
  • Glial tumor entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".


References
  1. Template:Wang, J., & Bettegowda, C. (2015). Genomic discoveries in adult astrocytoma. Current opinion in genetics & development, 30, 17-24.
  2. Bond, K. M., Hughes, J. D., Porter, A. L., Orina, J., Fang, S., & Parney, I. F. (2018). Adult pilocytic astrocytoma: an institutional series and systematic literature review for extent of resection and recurrence. World neurosurgery, 110, 276-283.
  3. Rogers, K. (2018, December 5). Ependymal cell. Retrieved from Encyclopeaedia Britannica: https://www.britannica.com/science/ependymal-cell
  4. National Cancer Registration and Analysis Service. (2010). Ependymal tumours of the brain and spinal cord: survival rates in England. Retrieved from NCRAS: http://www.ncin.org.uk/publications/data_briefings/ependymal_tumours_of_the_brain_and_spinal_cord_survival_rates_in_england
  5. Van Thuijl, H. F., Ylstra, B., Würdinger, T., van Nieuwenhuizen, D., Heimans, J. J., Wesseling, P., & Reijneveld, J. C. (2013). Genetics and pharmacogenomics of diffuse gliomas. Pharmacology & therapeutics, 137(1), 78-88.
  6. Van den Bent, M. J., Reni, M., Gatta, G., & Vecht, C. (2008). Oligodendroglioma. Critical reviews in oncology/hematology, 66(3), 262-272.
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