GVD (chemotherapy)

GVD is a chemotherapy regimen, used for salvage treatment of relapsed or refractory Hodgkin disease, including those patients who relapse after stem cell transplantation.[1]

GVD regimen consists of three drugs:

  1. (G)emcitabine
  2. (V)inorelbine
  3. (D)oxil - pegylated liposomal formulation of doxorubicin

Dosing
DrugDose in transplant-naive patientsDose in post-transplant patientsModeDays
(G)emcitabine1000 mg/m2800 mg/m2IV infusionDays 1, 8
(V)inorelbine20 mg/m215 mg/m2IV bolusDays 1, 8
(D)oxil15 mg/m210 mg/m2IV infusionDays 1, 8

Repeated every 21 days (3 weeks).

References
  1. Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin (GVD), a salvage regimen in relapsed Hodgkin's lymphoma: CALGB 59804
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.