Follicular hyperplasia

Follicular hyperplasia is a type of lymphoid hyperplasia. It is caused by a stimulation of the B cell compartment.[1] It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape.[2] Follicular hyperplasia is distinguished from follicular lymphoma in its polyclonality and lack of bcl-2 protein expression, whereas follicular lymphoma is monoclonal, and does express bcl-2[3]).

Follicular hyperplasia
Other namesReactive follicular hyperplasia, Lymphoid nodular hyperplasia

Causes

Some specific reactive lymphadenopathies with a predominantly follicular pattern:[4]

Diagnosis

Treatment

References
  1. Weiss, L. M.; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology. 26 Suppl 1: S88–96. doi:10.1038/modpathol.2012.176. PMID 23281438.
  2. Drew, Torigan; et al. (2001). "Lymphoid hyperplasia of stomach". American Journal of Roentgenology. 177 (1): 71–75. doi:10.2214/ajr.177.1.1770071. PMID 11418401.
  3. Sattar, Husain (2016). Fundamentals of Pathology. Chicago. ISBN 9780983224624.
  4. Weiss, L. M.; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology. 26 Suppl 1: S88–96. doi:10.1038/modpathol.2012.176. PMID 23281438.
  5. John H. Stone; Arezou Khosroshahi; Vikram Deshpande; et al. (October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & Rheumatism. 64 (10): 3061–3067. doi:10.1002/art.34593. PMC 5963880. PMID 22736240.


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