Fetal trimethadione syndrome

Fetal trimethadione syndrome (also known as paramethadione syndrome, German syndrome, tridione syndrome, among others[1]) is a set of birth defects caused by the administration of the anticonvulsants trimethadione (also known as Tridione) or paramethadione to epileptic mothers during pregnancy.[2]

Fetal trimethadione syndrome
Other namesGerman syndrome
Condition is caused by Trimethadione (and paramethadione)

Fetal trimethadione syndrome is classified as a rare disease by the National Institute of Health's Office of Rare Diseases,[3] meaning it affects less than 200,000 individuals in the United States.[4]

The fetal loss rate while using trimethadione has been reported to be as high as 87%.[5]

Presentation

Fetal trimethadione syndrome is characterized by the following major symptoms as a result of the teratogenic characteristics of trimethadione.[2][6]

Diagnosis

Treatment

References

  1. Additional names include trimethadione embryopathy and trimethadione syndrome.
  2. Multiple Congenital Anomaly/Mental Retardation (MCA/MR) Syndromes - Retrieved January 2007
  3. Fetal trimethadione syndrome on the ORD website. Retrieved January 2007
  4. NIH's Office of Rare Diseases Archived 2009-02-06 at the Wayback Machine Retrieved January 2007
  5. Teratology and Drug Use During Pregnancy Retrieved January 2007
  6. The fetal trimethadione syndrome: report of an additional family and further delineation of this syndrome Retrieved January 2007
Classification
External resources
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