Sodium calcium edetate

Sodium calcium edetate
Clinical data
Trade names	Calcium disodium versenate, others
Other names	edetate calcium disodium, sodium calcium edetate
AHFS/Drugs.com	Monograph
Pregnancy; category	US: B (No risk in non-human studies) ;
Routes of; administration	IV, IM
Drug class	chelating agent
ATC code	V03AB03 (WHO) ;
Identifiers
	IUPAC name Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate;
CAS Number	62-33-9;
PubChem CID	6093170;
DrugBank	DB00974;
ChemSpider	5883;
E number	E385 (antioxidants, ...)
CompTox Dashboard (EPA)	DTXSID2036409 ;
ECHA InfoCard	100.000.482
Chemical and physical data
Formula	C10H12CaN2Na2O8
Molar mass	374.270 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2];
	InChI InChI=1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4; Key:SHWNNYZBHZIQQV-UHFFFAOYSA-J;

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning.[1] This includes short term and long term lead poisoning.[2] For lead encephalopathy it is typically used together with dimercaprol.[2] It does not appear to be useful for tetraethyllead toxicity.[2] It is given by slow injection into a vein or into a muscle.[1]

Common side effects include pain at the site of injection.[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[1] Benefits when needed in pregnancy are likely greater than the risks.[2] Sodium calcium edetate is in the chelating agent family of medication.[2] It is a salt of edetate with two sodium and one calcium atoms.[3] It works by binding a number of heavy metals which allows them to leave the body in the urine.[2]

Sodium calcium edetate came into medical use in the United States in 1953.[2] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] In the United States a course of treatment costs 50 to 100 USD as of 2015.[5] Edetate disodium is a different formulation which does not have the same effects.[2]

Medical uses

The primarily use is to treat lead poisoning.[1] In lead toxicity it is an alternative to succimer.[2]

It may also be used for plutonium toxicity.[6]

History

Sodium calcium edetate came into medical use in the United States in 1953.[2]

References

WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.
"Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 2017-01-16.
"WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560.
Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 2017-01-16.

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[WHO2008-1] WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 January 2017.

[AHFS2017-2] "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.

[3] Kasture, Dr A. V. (2008). Pharmaceutical Chemistry - I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 2017-01-16.

[WHO19th-4] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.

[Ric2015-5] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 471. ISBN 9781284057560.

[6] Flanagan, Robert; Jones, Alison; Maynard, Robert L. (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 2017-01-16.