Dextran 70

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[2]

Dextran 70
Clinical data
Trade namesRescueFlow, others
AHFS/Drugs.comMonograph
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		intravenous
    ATC code
    Legal status
    Legal status
    Identifiers
    CAS Number
    DrugBank
    Chemical and physical data
    Molar mass70,000 Da

    Common side effects include vomiting, fever, and joint pains.[2] Other side effects include allergic reactions and poor blood clotting.[1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[2] Use is also not recommended during pregnancy.[3] It works by pulling fluid from the extravascular space into the blood vessels.[2]

    Dextran 70 was approved for medical use in 1947.[4] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[5] The wholesale cost in the developing world is about US$4.10–5.25 per 500 ml.[6] In the United Kingdom this dose costs the NHS about 57.00 pounds.[3] In the United States it costs about $25–50 per dose.[7] It comes in either sodium chloride solution or glucose solution.[2]

    References
    1. WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. X. ISBN 9789241547659. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    2. "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
    3. British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
    4. BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.
    5. "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Archived (PDF) from the original on 13 December 2016. Retrieved 8 December 2016.
    6. "Dextran 70 6% in Sod. chloride 0.9%". International Drug Price Indicator Guide. Retrieved 8 December 2016.
    7. Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 167. ISBN 9781284057560.
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