Crotylsarin

Crotylsarin (CRS) is an extremely toxic organophosphate nerve agent of the G-series.[1] Like other nerve agents, CRS irreversibly inhibits the acetylcholinesterase. However, since the inhibited enzyme ages so rapidly, the inhibited enzyme can't be reactivated by oxime reactivators.[2][3]

Crotylsarin
Names
IUPAC name
(2E)-2-Buten-1-yl methylphosphonofluoridate
Other names
CRS
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
PubChem CID
Properties
Chemical formula
 C5H10FO2P
Molar mass 152.105 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

See also

References
  1. Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst (27 June 2016). "Toxicology of organophosphorus compounds in view of an increasing terrorist threat". Archives of Toxicology. 90 (9): 2131–2145. doi:10.1007/s00204-016-1772-1. PMID 27349770.
  2. Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. (January 1991). "Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat". Toxicology. 69 (3): 331–344. doi:10.1016/0300-483x(91)90191-3.
  3. Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. (21 November 2012). "The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors". Archives of Toxicology. 87 (4): 711–719. doi:10.1007/s00204-012-0977-1. PMID 23179755.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.