Estradiol/norethisterone acetate

Estradiol/norethisterone acetate (E2/NETA), sold under brand names including Activella, Amabelz, Estracomb, Kliofem, and Novofem, is a combination of estradiol (E2) and norethisterone acetate (NETA) which is used in the treatment of vasomotor symptoms, vulvar and vaginal atrophy, and osteoporosis[1] associated with menopause.[2] Activella specifically is marketed by Novo Nordisk and is supplied as film-coated tablets containing 1 mg estradiol and 0.5 mg norethisterone acetate. CombiPatch is a combination of estradiol and NETA provided as a transdermal patch.[2]

Estradiol/norethisterone acetate
Combination of
EstradiolEstrogen
Norethisterone acetateProgestogen
Clinical data
Trade namesActivella, Amabelz, CombiPatch Estracomb, Kliofem, Novofem
AHFS/Drugs.comMonograph
MedlinePlusa601041
Pregnancy
category
  • US: X (Contraindicated)
    ATC code
    Legal status
    Legal status
    Identifiers
    CAS Number
    ChemSpider
    • none
     NY (what is this?)  (verify)

    See also

    References
    1. Morabito, Nunziata; Crisafulli, Alessandra; Vergara, Caterina; Gaudio, Agostino; Lasco, Antonino; Frisina, Nicola; D'Anna, Rosario; Corrado, Francesco; Pizzoleo, Maria Antonia; Cincotta, Maria; Altavilla, Domenica; Ientile, Riccardo; Squadrito, Francesco (1 October 2002). "Effects of Genistein and Hormone-Replacement Therapy on Bone Loss in Early Postmenopausal Women: A Randomized Double-Blind Placebo-Controlled Study". Journal of Bone and Mineral Research. 17 (10): 1904–1912. doi:10.1359/jbmr.2002.17.10.1904.
    2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020870s023lbl.pdf



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